CAS 94-20-2 MFCD00079004-Chlorpropamide 1-(4-氯苯磺酰基)-3-丙脲 TAO{mole}

Chlorpropamide 1-(4-氯苯磺酰基)-3-丙脲

CAS 94-20-2 MFCD00079004

化学结构图

SMILES: CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1

化学属性

Mol. Formula	C10H13ClN2O3S
Mol. Weight	277
TSCA	No
Appearance	白色结晶性粉末。熔点127-129℃。易溶于氯仿和丙酮，略溶于乙醚、苯、在pH为6的水中溶解度为2.2mg/ml，在pH7.3的水中不溶。无臭，无味。
Melting Point	127-130
Solubility	DMSO 55 mg/mL Water <1 mg/mL Ethanol 55 mg/mL

别名和识别编码

Chemical Name	Chlorpropamide
CAS Number	94-20-2
Synonym	NCI-C01752 N-Propyl-N'-(p-chlorobenzenesulfonyl)urea { 特泌胰 4-Chloro-N-[(propylamino)-carbonyl]benzenesulfonamide {hazar Diabeneza Chloronase Meldian Benzenesulfonamide, 4-chloro-N-[(propylamino)carbonyl]- ######## {Chemicalb 4-Chloro-4-((propylamino)carbonyl)benzenesulfonamide N-(p-Chlorobenzenesulfonyl)-N'-propylurea 1-p-Chlorophenyl-3-(propylsulfonyl)urea CHLOROPROPAMIDE N’-丙基-N’-对氯苯磺酰基脲对氯苯磺酰丙脲 1-(p-Chlorobenzenesulfonyl)-3-propylurea 1-Propyl-3-(p-chlorobenzenesulfonyl)urea Benzenesulfonamide, 4-chloro-N-((propylamino)carbonyl)- Mellinese 1-(4-CHLOROPHENYLSULFONYL)-3-PROPYLUREA Diabaril 1-[P-CHLOROBENZENESULFONYL]-3-PROPYLUREA 氯磺丙脲 1-((p-chloropenyl)sulfonyl)-3-propyl-ure Prodiaben P 607 {h 4-chloro-n-[(propylamino)carbonyl]benzenesulfonamide Glisema 4-chloro-n-[(propylamino)carbonyl]-benzenesulfonamid 4-chloro-n-((propylamino)carbonyl)-benzenesulfonamid Diabenese U-3818 N-Propyl-N'-p-chlorphenylsulfonylcarbamide Diabexan 1-(4-Chlorobenzenesulfonyl)-3-n-propylurea 1-(p-Chlorophen 4-Chloro-N-[(propylamino)carbonyl]benzene-sul-fonamide Diabinese CHLORPROPAMIDE Diabenal Adiaben 1-(4-Chlorophenylsulfonyl)-3-propylurea Diabet-pages 特泌胰;对氯苯磺酰丙脲;1-(4-氯苯磺酰基)-3-丙脲;N'-丙基-N'-对氯苯磺酰基脲 1- Diabetoral 1-((p-chlorophenyl)sulfonyl)-3-propyl-ure Chlorpropamide bioglumin Chloropropamide
MDL Number	MFCD00079004
PubChem Substance ID	2727
EC Number	202-314-5
Merck Number	2186
Reaxys-RN	2218363
Chemical Name Translation	1-(4-氯苯磺酰基)-3-丙脲
Beilstein Registry Number	2218363
Wiswesser Line Notation	GR DSWMVM3
LabNetwork Molecule ID	LN00196005
InChI	InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)

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产品应用

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安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H332 Harmful if inhaled 吸入有害
H351 Suspected of causing cancer 怀疑致癌
H312 Harmful in contact with skin 皮肤接触有害
H312+H332
H303 May be harmfully swallowed 吞食可能有害

RTECSYS6650000

Signal word Warning

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；

Hazard Codes Xn

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

Storage condition 储存温度-20°C

TYPE OF TEST            : TD

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSER

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 25 mg/kg/5D-I
TOXIC EFFECTS :
   Blood - other hemolysis with or without anemia
REFERENCE :
   DICPBB Drug Intelligence and Clinical Pharmacy.  (POB 42435, Cincinnati, OH
   45242)  V.3-    1969-  Volume(issue)/page/year: 18,981,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 580 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 409 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (3),36,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 83 mg/kg/25D-I
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from large intestine
   Liver - jaundice, cholestatic
REFERENCE :
   AJGAAR American Journal of Gastroenterology.  (American College of
   Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202)  V.21-
   1954-  Volume(issue)/page/year: 80,381,1985

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 177 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 77,349,1980

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 2 gm/L
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (96),55,1978

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2400 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 250 mg/L/30H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 56,215,1977

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 7100 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amste

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 166 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/pag

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 1358 mg/kg
SEX/DURATION            : female 1-26 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,187,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 884 mg/kg
SEX/DURATION            : female 1-35 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   ADCHAK Archives of Disease in Childhood.  (British Medical Journal, POB
   560B, Kennebunkport, ME 04046)  V.1-    1926-  Volume(issue)/page/year:
   49,283,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   PROEAS Problemy Endokrinologii.  Problems of Endocrinology.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-6, 1936-41; 13-    1967-
   Volume(issue)/page/year: 14,89,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 180 mg/kg
SEX/DURATION            : female 26-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive

其他信息

Sigma Aldrich:94-20-2(sigmaaldrich)
上游原料:丁酰胺 --> 4-氯苯磺酰胺 --> 异氰酸丙酯
MOL 文件:94-20-2.mol
图谱信息:氯磺丙脲(94-20-2)红外图谱(IR1) 氯磺丙脲(94-20-2)核磁图( 1 HNMR) 氯磺丙脲(94-20-2)核磁图( 13 CNMR) 氯磺丙脲(94-20-2)质谱(MS) 氯磺丙脲(94-20-2)红外图谱(IR2)
氯磺丙脲价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 C1220 1-(4-氯苯磺酰基)-3-丙脲 1-(4-Chlorophenylsulfonyl)-3-propylurea 500G 4600元 2014/06/02 C1220 1-(4-氯苯磺酰基)-3-丙脲 1-(4-Chlorophenylsulfonyl)-3-propylurea 25G 623元
TCI Shanghai:1-(4-氯苯基磺酰基)-3-丙脲 1-(4-Chlorophenylsulfonyl)-3-propylurea,>;99.0%(T)(94-20-2)
方法一:由对氯苯磺酰胺与丁酰胺反应而得对氯苯磺酰丙脲钠盐。再用盐酸酸化、精制而得成品。另一种方法是以对氯苯磺酰胺、异氰酸丙酯、三乙胺为原料。
用途一:磺脲类口服降血糖药。作用强而持久，主要选择性地作用于胰岛-β-细胞，促进胰岛的分泌，使血糖降低。用于糖尿病。氯磺丙脲具有比较大的副作用，所以该药的使用量有逐年减少的趋势。