CAS 94-13-3 MFCD00002354-Propyl Paraben 对羟基苯甲酸丙酯 TAO{mole}

Propyl Paraben 对羟基苯甲酸丙酯

CAS 94-13-3 MFCD00002354

化学结构图

SMILES: CCCOC(=O)c1ccc(O)cc1

化学属性

Mol. Formula	C10H12O3
Mol. Weight	180.20
Melting Point	95-98°C
Density	1.063
Flash Point	124.6°C
TSCA	Yes
Boiling Point	294.3°C at 760 mmHg
Solubility	<0.1 G/100 ML AT 12 ºC
Refractive index	1.5050

别名和识别编码

Chemical Name	Propyl Paraben
CAS Number	94-13-3
Synonym	Propylparaben {LY} Propylparaben {} {LY} Propylparaben {} {} {LY} Propylparaben {} {} {} {LY} Propylparaben {} {} {} {} {LY} Propylparaben {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propylparaben {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Beilstein Registry Number	1103245
EC Number	202-307-7
MDL Number	MFCD00002354
Reaxys-RN	1103245
PubChem Substance ID	87570648
Merck Number	7866
Chemical Name Translation	对羟基苯甲酸丙酯
Wiswesser Line Notation	QR DVO3
LabNetwork Molecule ID	LN00220908
InChI	InChI=1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3
Canonical SMILES	O=C(OCCC)C1=CC=C(O)C=C1

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

An antimicrobial

安全信息

GHS Symbol

WGK Germany1

Signal word Warning

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

RTECSDH2800000

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P352+P333+P313+P362+P364
P305+P351+P338
P305+P351+P338+P337+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xi

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 128,135,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6332 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NEZAAQ Nippon Eiseigaku Zasshi.  Japanese Journal of Hygiene.  (Nippon Eisei
   Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606,
   Japan)  V.1-    1946-  Volume(issue)/page/year: 28,463,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 146,208

其他信息

方法二:由对羟基苯甲酸与正丙醇在硫酸存在下酯化而得。
Acros Organics:对羟基苯甲酸丙酯 Propyl 4-hydroxyben
海关编码:29182930
毒性分级:中毒
FEMA:2951
参考质量标准二:GB 8851-1988 含量/%≥@99.0 熔点/℃@95~98 硫酸盐(以SO4 2- 计)/%@≤0.024 灼烧残渣/%@≤0.5 酸度试验@合格对羟基苯甲酸及水杨酸试验@合格干燥失重/%@≤0.5 重金属(以Pb计)/%@≤0.001 砷(以As计)/%@≤0.0001
上游原料:硫酸 --> 对羟基苯甲酸 --> 酯化釜 --> 丙醇 --> 尼泊金乙酯
{Chemica
参考质量标准一:GB 885—88 FAO WHO，1998(强制性国标) 含量(以干基计) ≥99.0% ≥99.0% 熔点 95～98℃ - 干燥失重 ≤0.5% ≤0.5%(硅胶，5h) 硫酸盐(以SO4计) ≤0.024% ≤0.05%(GT-5-1，试样2g 灼烧残渣 ≤0.05% - 酸度试验合格正常对羟基苯甲酸及水杨酸试验合格正常砷(以As计) ≤0.0001% - 重金属(以Pb计) ≤0.001% 铅(原子吸收光谱法) ≤2mg/kg
易溶于醇和醚，在水中几乎不溶。
灭火剂:水, 二氧化碳, 干粉, 砂土
用途四:防腐剂；抗微生物剂。
类别:有毒物质
用途五:用作食品、化妆品、药物等的防腐杀菌剂。
{
Alfa Aesar:对羟基苯甲酸正丙酯,99% n-Propyl 4-hydroxybenzoate, 99+%(94-13-3)
尼泊金丙酯价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30158570 对羟基苯甲酸丙酯 1kg 110元 2011/08/23 30158526 对羟基苯甲酸丙酯 100g 26.7元 2011/08/23 K5479001 4-羟基苯甲酸丙酯;对羟基安息香酸丙酯; 尼泊金丙酯 100g 262元
所属类别一:食品添加剂: 防腐剂
MSDS 信息:对羟基苯甲酸丙酯(94-13-3).msds
Acros Organics:对羟基苯甲酸丙酯 P
外观性质:白色粉末。
用途二:用作防腐剂及抗氧化剂，也用于制药工业
方法一:将对羟基苯甲酸和正丙醇依次加入酯化釜，加热搅拌使其溶解，慢慢加入浓硫酸后加热回流酯化8h；然后趁热将反应液放入4%的碳酸钠溶液，不断搅拌析出结晶，离心过滤水洗至中性即为粗品；再经活性炭脱色、乙醇重结晶即得成品。也可参照对羟基苯甲酸乙酯的制法。 HOC6H4COOH+C3H7OH[H2SO4]→HOC6H4COOC3H7
图谱信息:尼泊金丙酯(94-13-3)红外图谱(IR1) 尼泊金丙酯(94-13-3)质谱(MS) 尼泊金丙酯(94-13-3)核磁图( 13 CNMR) 尼泊金丙酯(94-13-3)Raman光谱尼泊金丙酯(94-13-3)红外图谱(IR2) 尼泊金丙酯(94-13-3)核磁图( 1 HNMR)
使用限量:GB 2760--2002(以对羟苯甲酸计；g/kg)：果蔬保鲜0.012；食醋0.10；碳酸饮料0.20;果汁(果味)型饮料、果酱(不包括罐头)、酱油酱料，0.25；糕点馅，0.5(单一用或与对羟苯甲目乙酯混合用总量)；蛋黄馅0.20。另规定对羟基苯甲酸甲酯钠亦等同应用。 FAO/WHO(1984)：果酱和果冻，1000mg/kg FDA§184．1670(2000)：0.1%。 EEC(1990，mg/kg)：冷冻饮品160；甜菜酸渍菜、沙拉酱，250；香料、水
毒性:Adl 0-10mg/kg(FAO/WHO，2001)。 LD 50 3.7g/kg(小鼠，经口)。 GRAS(FDA，§184．1670，2000)。 HACSG列为限用名单。