(R)-2-Amino-7-(4-Fluoro-2-(6-Methoxypyridin-2-Yl)Phenyl)-4-Methyl-7,8-Dihydropyrido[4,3-d]Pyrimidin-5(6H)-One (R)-2-氨基-7-(4-氟-2-(6-甲氧基吡啶-2-基)苯基)-4-甲基-7,8-二氢吡啶并[4,3-d]嘧啶-5(6H)-酮
CAS 934343-74-5 MFCD034343745
化学结构图
SMILES: COc1cccc(-c2cc(F)ccc2[C@H]2Cc3nc(N)nc(C)c3C(=O)N2)n1
化学属性
| Mol. Formula | C20H18FN5O2 |
|---|---|
| Mol. Weight | 379.39 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (R)-2-Amino-7-(4-Fluoro-2-(6-Methoxypyridin-2-Yl)Phenyl)-4-Methyl-7,8-Dihydropyrido[4,3-d]Pyrimidin-5(6H)-One |
|---|---|
| Chemical Name Translation | (R)-2-氨基-7-(4-氟-2-(6-甲氧基吡啶-2-基)苯基)-4-甲基-7,8-二氢吡啶并[4,3-d]嘧啶-5(6H)-酮 |
| Chemicalbook ID | CB22570378 |
| Synonym | HSP990; HSP-990; HSP 990; NVP HSP 990; NVP-HSP990; NVP HSP-990; NVP-HSP990 |
| Formula | C20H18FN5O2 |
| IUPAC Name | (R)-2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one |
| InChIKey | WSMQUUGTQYPVPD-OAHLLOKOSA-N |
| InChI | InChI=1S/C20H18FN5O2/c1-10-18-16(26-20(22)23-10)9-15(25-19(18)27)12-7-6-11(21)8-13(12)14-4-3-5-17(24-14)28-2/h3-8,15H,9H2,1-2H3,(H,25,27)(H2,22,23,26)/t15-/m1/s1 |
| Canonical SMILES | O=C1N[C@@H](C2=CC=C(F)C=C2C3=NC(OC)=CC=C3)CC4=NC(N)=NC(C)=C41 |
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产品应用
- HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.
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