5-AIQ HYDROCHLORIDE
CAS 93117-07-8 MFCD03452659
化学结构图
SMILES: Cl.NC1=CC=CC2C(=O)NC=CC=21
化学属性
| Mol. Formula | C9H9ClN2O |
|---|---|
| Mol. Weight | 196.63 |
别名和识别编码
| Chemical Name | 5-AIQ hydrochloride |
|---|---|
| Synonym | 5-Aminoisoquinolinone hydrochloride |
| MDL Number | MFCD03452659 |
| PubChem Substance ID | 24724396 |
| CAS Number | 93117-07-8 |
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分类
- {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, P to Q, PARP Poly(ADP-ribose) Polymerase, 生化试剂, 生物活性小分子, 细胞生物学, 酶、抑制剂和底物
- {SNA} A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q, PARP Poly(ADP-ribose) Polymerase
相关文献及参考
- Rajesh, M., et al., Poly(ADP-ribose)polymerase inhibition decreases angiogenesis Biochem. Biophys. Res. Commun. 350 , 1056-62, (2006)
- Li, M., et al., Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells Pathobiology 76 , 108-16, (2009)
- Nicolescu, A.C., et al., Inhibition of matrix metalloproteinase-2 by PARP inhibitors Biochem. Biophys. Res. Commun. 387 , 646-50, (2009)
- Di Paola, R., et al., Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. Eur. J. Pharmacol. 492 , 203-210, (2004) 摘要
- Cuzzocrea, S., et al., Effects of 5-aminoisoquinolinone, a water-soluble, potet inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochem. Pharmacol. 63 , 293-304, (2002)
- McDonald, M.C., et al., Effects of 5-aminoisoquinolinone, a water-soluble, potet inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. Br. J. Pharmacol. 130 , 843-850, (2000)
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
