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分类

• {SNA} Analytical Standards,
• {
• {SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards G - H, 分析/色谱
• {SNA} Building Blocks, C10,
• {SNA} Analytical Standards, Pharmacopeia Metrological Institutes Standards, USP Standards, USP Standards G - H, 分析/色谱
• {SNA} Additional Standa
• {SNA} Analytical Standards, Analytical/Chromatography,

产品应用

• A compound with expectorant and sedative properties.

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 495 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,398,1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2553 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATHPAB Applied Therapeutics.  (Seccombe House Unlimited, Toronto, Canada)
   V.2(9)-12, 1960-70.  Volume(issue)/page/year: 9,55,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1510 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   PLRCAT Pharmacological Research Communications.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1969-  Volume(issue)/page/year:
   1,413,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 pe

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 335 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto

其他信息

• 图谱信息:愈创甘油醚(93-14-1)红外图谱(IR1) 愈创甘油醚(93-14-1)核磁图( 1 HNMR) 愈创甘油醚(93-14-1)质谱(MS) 愈创甘油醚(93-14-1)红外图谱(IR2) 愈创甘油醚(93-14-1)核磁图( 13 CNMR)
• Acros Organics:愈创木酚甘油醚 3-(2-Methoxyphenoxy)-1,2-propanediol, 99%(93-14-1)
• 用途一:祛痰镇咳，适用于多痰咳慢性支气管炎、支气管扩张等病症
• MOL 文件:93-14-1.mol
• Hazard Note:Harmful
• Sigma Aldrich:93-14-1(sigmaaldrich)
• 愈创甘油醚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 G0159 愈创甘油醚 Guaiacol Glycerol Ether 500G 1490元 2014/06/02 G0159 愈创甘油醚 Guaiacol Glycerol Ether 25G 263元 2010/06/21 352511000 愈创甘油醚 3-(2-Methoxyphenoxy)-1,2-propanediol 99% 100 GR 909元
• 下游产品:氧化锌 --> 立德粉 --> 六水合硝酸锌 --> 美索巴莫
• 镇咳祛痰类非处方药:愈创甘油醚是一种祛痰剂，又称愈甘醚、甲甘苯二醚、愈创木酚甘油醚、甘油愈创木酯，口服后能刺激胃黏膜反射性引起支气管黏膜腺体分泌增加，降低痰的黏性，使黏痰易于咳出。并具有消毒防腐作用，可减少痰液的恶臭味，还具有镇咳、解痉、抗惊厥作用，用于慢性支气管炎的多痰咳嗽、肺脓肿、支气管扩张和继发性哮喘，多与其他镇咳平喘药合用。 愈创甘油醚可从胃肠道吸收，并在1～3小时后达到血药浓度峰值。大部分自肠道排出，少量代谢为葡糖醛酸结合物随尿迅速排出。
• 方法一:由愈创木酚钠与3-氯丙二醇缩合而得。将氢氧化钠溶液和愈创木酚在40℃配制成酚钠，加入3-氯-1，2-丙二醇，自然升温至95℃，于92-98℃反应3h，静置，分去盐水层，加盐酸酸化至pH为3-5，冷却结晶，甩滤。滤饼用乙醇重结晶，得愈创甘油醚。收率约60%。
• 用途二:该品为祛痰镇咳药。
• 上游原料:氢氧化铵 --> 碳酸二乙酯 --> 愈创木酚 --> 3-氯-1,2-丙二醇
• Guaifenesin 是一种祛痰药。
• TCI Shanghai:愈创甘油醚 Guaiacol Glycerol Ether,>;98.0%(LC)(E)(93-14-1)
• 愈创甘油醚
• Alfa Aesar:3-(2-甲氧基苯氧基)-1,2-丙烷二醇,erythro+threo,99+% 3-(2-Methoxyphenoxy)-1,2-propanediol, 99+%(93-14-1)