CAS 924-42-5 MFCD00004597-N-(Hydroxymethyl)acrylamide N-(羟甲基)丙烯酰胺 TAO{mole}

N-(Hydroxymethyl)acrylamide N-(羟甲基)丙烯酰胺

CAS 924-42-5 MFCD00004597

化学结构图

SMILES: C=CC(=O)NCO

化学属性

Mol. Formula	C4H7NO2
Mol. Weight	101.11
Refractive index	n20/D 1.413
Density	1.074 g/mL at 25 °C
Melting Point	75.0 to 79.0 deg-C
Solubility	<0.1 G/100 ML AT 20.5 ºC
Stability	对光敏感
Flash Point	100°C
Boiling Point	277°C(lit.)

别名和识别编码

Chemical Name	N-(Hydroxymethyl)acrylamide
CAS Number	924-42-5
PubChem Substance ID	13543
Beilstein Registry Number	506646
MDL Number	MFCD00004597
Reaxys-RN	506646
EC Number	213-103-2
Synonym	N-MAN Monomethylolacrylamide N-羟甲基丙烯酰胺 N-Methylolacrylamide NM-AMD Methylolacrylamidesolution N-(Hydroxymethyl)acrylamide N-(羟甲基)丙烯酰胺溶液 Acrylamide, N-(hydroxymethyl)- n-(hydroxymethyl)-2-propenamid N-Methyloacrylamide N-甲基戊烯聚合物 N-羥甲基丙烯醯胺 N-(Hydroxymethyl)-2-propenamide; N-(Hydroxymethyl)acrylamide N-METHYLOLACRYLAMIDE N-羟甲基-2-丙烯酰胺 N-(HYDROXYMETHYL)ACRYLAMIDE SOLUTION, ST AB., ~48% IN H2O N-Methanolacrylamide 2-Propenamide, N-(hydroxymethyl)- n-(hydroxymethyl)-2-propenamide Yuramin T 80 NCI-C60333 METHYLOLACRYLAMIDE
Chemical Name Translation	N-(羟甲基)丙烯酰胺
Wiswesser Line Notation	Q1MV1U1
LabNetwork Molecule ID	LN00222801
InChI	InChI=1S/C4H7NO2/c1-2-4(7)5-3-6/h2,6H,1,3H2,(H,5,7)

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产品应用

有机合成单体可用于制备多种共聚物。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H301 Toxic if swallowed 吞食有毒
H350 May cause cancer 可能致癌
H340 May cause genetic defects 可能导致遗传性缺陷
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
H315 Causes skin irritation 会刺激皮肤
H302 Harmful if swallowed 吞食有害
H335 May cause respiratory irritation 可能导致呼吸道刺激
H319 Causes serious eye irritation 严重刺激眼睛
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard Codes T Xn

Precautionary statements

P308+P311
P305+P351+P338
P308+P313
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P201 Obtain special instructions before use. 使用前获取专门指示。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P332+P313
P302+P352+P333+P313+P362+P364
P405 Store locked up. 上锁保管。
P301+P310
P305+P351+P338+P337+P313
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P301+P310+P330

Signal word

RTECSAS3600000

Storage condition 0-10 遇光、热易发生自聚，2-8℃保存 2-8℃保存 0-10°C Refrigerator

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R46 May cause inheritable genetic damage 可能引起遗传基因损害
R48/20/21/22
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R45 May cause cancer 可能致癌
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

UN Number 2810 2811

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25750 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-352,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 563 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   19,2591,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 474 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NEZAAQ Nippon Eiseigaku Zasshi.  Japanese Journal of Hygiene.  (Nippon Eisei
   Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606,
   Japan)  V.1-    1946-  Volume(issue)/page/year: 34,183,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 1,306,1978

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 16 gm/kg
TOXIC EFFECTS :
   Behavioral - tremor
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,111,1990

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 375 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-352,1989

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 250 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-352,1989

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 730 mg/kg/6W (Continuous)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   59,201,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4608 mg/kg
SEX/DURATION            : male 16 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   47,179,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 730 gm/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   59,201,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 730 gm/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   59,201,1986

Hazard Class6.1

Packing GroupIII

其他信息

N-羟甲基丙烯酰胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30201428 N-羟甲基丙烯酰胺 500g 44元 2011/04/16 M0574 N-(羟甲基)丙烯酰胺 N-(Hydroxymethyl)acrylamide 500G 526元 2011/04/16 M0574 N-(羟甲基)丙烯酰胺 N-(Hydroxymethyl)acrylamide 25G 195元
外观性质:白色结晶粉末。
用途三:有机合成单体可用于制备多种共聚物。
MSDS 信息:N-羟甲基丙烯酰胺(924-42-5).msds
上游原料:甲醛 --> 丙烯腈 --> 丙烯酰胺
用途一:可作交联剂，广泛用于纤维的改性树脂、加工染料、塑料粘合剂、土壤稳定剂等
方法一:在弱碱性条件下，将丙烯酰胺与37%的甲醛水熔液反应而制得。
用途二:该品分子中具有与羰基共轭的双键和富有反应性的羟甲基，是用途广泛的交联性单体，用于纤维的改性、树脂加工、粘合剂及纸张、皮革、金属表面的处理剂，还可用于土壤改良剂等。雄小鼠口服LD50为420mg/kg。
MOL 文件:924-42-5.mol
下游产品:无纺布胶 --> 涂料印花粘合剂
Sigma Aldrich:924-42-5(sigmaaldrich)
本品是一种自交型活性单体，在分子结构中，有与羟基共轭的双健又有活性的官能基，极易溶于水和醇中，难溶于氯仿及四氯化碳，在潮湿的空气中易于自聚交联成不溶性树脂，特别是在酸性条件下聚合更快。
TCI Shanghai:N-羟甲基丙烯酰胺 N-(Hydroxymethyl)acrylamide,>;98.0%(T)(924-42-5)