Phosphonic acid,(1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethyl)-, diethyl ester
CAS 92118-27-9 MFCD00866278
化学结构图
SMILES: CC(NC(=O)N(CCCl)N=O)P(=O)(OCC)OCC
化学属性
| Mol. Formula | C9H19ClN3O5P |
|---|---|
| Mol. Weight | 315.69 |
别名和识别编码
| Chemical Name | Fotemustine |
|---|---|
| Synonym | Diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate Fotemustina Fotemustine Mustophorane (+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate Muphoran P-[1-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-phosphonic acid diethyl ester S 10036 S 10036 Servier-10036 |
| MDL Number | MFCD00866278 |
| CAS Number | 92118-27-9 |
| PubChem Substance ID | 329799764 |
| Chemical Name Translation |
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分类
- {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA Intercalators and Crosslinkers, DNA metabolism, F, Servier
- {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, DNA Intercalators and Crosslinkers, DNA metabolism, F, Servier, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
安全信息
GHS Symbol
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H351 Suspected of causing cancer 怀疑致癌
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,6782,1987
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 5 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Parenteral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 50 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993
TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 5100 ug/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993
TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 5 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993
TYPE OF TEST : Specific locus test ROUTE OF EXPOSURE : Multiple routes TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 100 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993
