Heparin Sodium Salt 肝素钠
CAS 9041-08-1 MFCD00081689
化学结构图
SMILES:
化学属性
| Mol. Weight | 1134.93 |
|---|---|
| Mol. Formula | |
| TSCA | Yes |
| Solubility | Soluble in water (100 mg/ml), DMSO (< 1 mg/ml), and ethanol (< 1 mg/ml). |
别名和识别编码
| MDL Number | MFCD00081689 |
|---|---|
| CAS Number | 9041-08-1 |
| Merck Number | 14,4653 |
| EC Number | 232-681-7 |
| Synonym | Tinzaparin sodium 肝磷脂;肝素;肝磷脂钠盐 Sodium heparinate ALFA 87-247 Reviparin sodium 肝素 钠 肝素 钠盐 来源于猪肠粘膜 Dalteparin sodium Pularin Hed-heparin Enoxaparin sodium PK 10169 Depo-Heparin 肝素钠 Hepathrom Sodium acid heparin Heparin sodium ALFA 87-198 ALFA 87-120 Sodium heparin ALFA 87-81 Parnaparin sodium 肝磷脂; 6-[5-Acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-3-[5-(6-carboxy-4,5-dihydroxy-3-sulfooxyoxan-2-yl)oxy-6-(hydroxymethyl)-3-(sulfoamino)-4-sulfooxyoxan-2-yl]oxy-4-hydroxy-5-sulfooxyoxane-2-carboxylic acid Liquemin ALFA 87-163 肝磷脂,肝素 Liquaemin sodium 肝磷脂钠盐 |
| Chemical Name | Heparin Sodium Salt |
| Chemical Name Translation | 肝素钠 |
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信息真实价格透明
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分类
- {SNA} Analytical Standards, EP Standards, EP Standards E - F, Pharmacopeia Metrological Institutes Standards, 分析/色谱
- {SNA} Biochemicals
- {SNA} Ana
- {SNA} Analytical Standards, Pharmacopeia Metrological Institutes Standards, USP Standards, USP Standards G - H, 分析/色谱
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards E - F, Pharmaceutical Standards, Pharmacopeia Standards
- {SNA} Carbohydrates,
- Anticoagulants, Bioactive Small Molecules, Biochemicals and Reagents, Blood, Carbohydrates,
- {SNA} Carbohydrates, Carbohydrates A to Z, Carbohydrates H-L, Core Bioreagents, Polysaccharide,
产品应用
- 生化研究，防止凝血酶原转变成凝血酶。
相关文献及参考
- Merck: 14,4653
- [1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412.
- [2]. Anurag Purushothaman, et al. Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. J Biol Chem. 2016 Jan 22;291(4):1652-63.
安全信息
GHS Symbol
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >779000 iu/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 23,201,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Human - woman DOSE/DURATION : 1400 units/kg/1W-I TOXIC EFFECTS : Nutritional and Gross Metabolic - changes in potassium REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 145,1070,1985
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Human - man DOSE/DURATION : 7 mg/kg/4D TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 244,1831,1980
TYPE OF TEST : TDLo - Lowest
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2800 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 102,156,1951
其他信息
- 几乎无臭。无味。为一种天然多糖，取自猪或牛肠粘液或牛肺。有吸湿性。易溶于水(1g溶于20ml水)，溶于盐水溶液，几乎不溶于乙醇、乙醚、丙酮、氯仿和苯。1%的水溶液pH为6.0-7.5。半数致死量(大鼠，静脉)354mg/kg。
