Cholera Toxin from Vibrio cholerae Cholera
CAS 9012-63-9 MFCD00130776
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分类
- {SNA} Bacteria, Bioactive Small Molecules, C-CH, Cell Signaling and Neuroscience, G Protein Function, G Proteins and Cyclic Nucleotides, Reagents,
- Bacteria, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, G Protein Function, G Proteins and Cyclic Nucleotides, Reagents, Toxins and Venoms
- {SNA} Bacteria, Bioactive Small Molecule Alphabetical Index, C-CH, G Protein Function, G Proteins and Cyclic Nucleotides, Reagents, Toxins and Venoms, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Tsai SC, et al. Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain. J Biol Chem. 1988;263(4):1768-1772.
- [3]. Wernick NL, et al. Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel). 2010;2(3):310-325.
- Andersen, S.M., et al., Topical Application Of Valrubicin Has A Beneficial Effect On Developing Skin Tumors. Carcinogenesis 31 , 1483-90, (2010) 摘要
- Androutsellis-Theotokis, A., et al., Cholera Toxin Regulates A Signaling Pathway Critical For The Expansion Of Neural Stem Cell Cultures From The Fetal And Adult Rodent Brains. PLoS ONE 5 , e10841, (2010) 摘要
- Debnath, J., Detachment-induced Autophagy In Three-dimensional Epithelial Cell Cultures. Meth. Enzymol. 452 , 423-39, (2009) 摘要
- Evers, D.L., et al., The Liposome PCR Assay Is More Sensitive Than The Vibrio Cholerae Enterotoxin And Escherichia Coli Heat-labile Enterotoxin R
安全信息
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P273 Avoid release to the environment. 避免释放到环境中。
- P301+P310
- P302+P350
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P301+P310+P330
- P302+P352+P310
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
- H300+H310
GHS Symbol
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- R52/53
- R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 260 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IMLCAV Immunological Communications. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1972- Volume(issue)/page/year: 1,223,1972
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 19,701,1981
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 10 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - food intake (animal) Lungs, Thorax, or Respiration - dyspnea REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 18,309,1980
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 10 ug/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,377,1987
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE : 40 ug/kg SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 45,315,1975
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE : 8 ug/kg SEX/DURATION : female 4-6 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion REFERENCE : IMLCAV Immunological Communications. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1972- Volume(issue)/page/year: 1,223,1972