CAS 9004-54-0 MFCD00130935-Dextran 右旋糖苷 TAO{mole}

Dextran 右旋糖苷

CAS 9004-54-0 MFCD00130935

化学结构图

SMILES: CC[C@H]1OC(COC[C@H]2OC(COC)[C@@H](O)C(OC)C2O)[C@@H](O)C(O)C1O

化学属性

Mol. Formula	N/A
Mol. Weight	MFCD00130935
Density	1.047
Stability	对湿度敏感
Solubility	Soluble in water (100 mg/ml), DMSO (freely), formamide (freely), ethylene glycol (freely), and glycerol (freely)

别名和识别编码

MDL Number	MFCD00130935
CAS Number	9004-54-0
EC Number	232-677-5
Synonym	DEXTRAN 40 Dextran Dextran 40 Dextran 40000 Dextran 70 Dextran 75 Dextran 80 Dextran B 1355 Dextran B 1355 S Dextran B-1355 Dextran B-1355-S Dextran B1355 Dextran B512 Dextran Derivatives Dextran M 70 Dextran T 40 Dextran T 500 Dextran T 70 Dextran T-40 Dextran T-500 Dextrans Hemodex Hyskon Infukoll Low molecular dextran-L Macrodex Mucrose; Glucose polymer Polyglucin Promit Rheodextran Rheoisodex Rheomacrodex Rheopolyglucin Rondex Saviosol 右旋糖酐,葡聚精右旋糖酐; 葡聚精葡聚糖来源于明串珠菌属葡聚糖来源于肠系膜明串珠菌葡聚糖溶液来源于肠系膜明串珠菌
Chemical Name	Dextran
Chemical Name Translation	右旋糖苷
Beilstein Registry Number	232-677-5
PubChem Substance ID	4125253
InChI	InChI=1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

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产品应用

用于校准测定高分子材料分子量的仪器、评价测量方法和给高分子材料分子量特性量值赋值。

安全信息

WGK Germany2

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

RTECSHH9230000

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

GHS Symbol

Precautionary statements

P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。

Storage condition 储存温度2-8℃ 密封阴凉干燥保存。储存温度 2-8°C ,充氩储存储存温度2-8℃,充氩保存

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - tumors
   Skin and Appendages - tumors
REFERENCE :
   AMPLAO AMA Archives of Pathology.  (Chicago, IL)  V.50(4)-69, 1950-60.  For
   publisher information, see APLMAS.  Volume(issue)/page/year: 67,589,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   AMPLAO AMA Archives of Pathology.  (Chicago, IL)  V.50(4)-69, 1950-60.  For
   publisher information, see APLMAS.  Volume(issue)/page/year: 67,589,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8000 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   AMPLAO AMA Archives of Pathology.  (Chicago, IL)  V.50(4)-69, 1950-60.  For
   publisher information, see APLMAS.  Volume(issue)/page/year: 67,589,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8000 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   AMPLAO AMA Archives of Pathology.  (Chicago, IL)  V.50(4)-69, 1950-60.  For
   publisher information, see APLMAS.  Volume(issue)/page/year: 67,589,1959

TYPE OF TEST

TYPE OF

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1023,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1023,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 13500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   GETRE8 Gematologiya i Transfuziologiya.  Hematology and Transfusion Science.
    (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.28-    1983-
   Volume(issue)/page/year: 31(10),38,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1023,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraveno

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE                    : 2 mL/kg
SEX/DURATION            : female 38 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   DRSAEA Drug Safety.  (Adis International Ltd.,  Private Bag 65901, Mairangi
   Bay, Auckland 10, New Zealand)  V.5-    1990-  Volume(issue)/page/year:
   7,71,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 675 gm/kg
SEX/DURATION            : female 8-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1119,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 3640 gm/kg
SEX/DURATION            : male 91 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 3,369,1975

其他信息

易溶于水。微溶于乙醇，在中性溶液中很稳定，遇强酸及升高温度下被水解，在碱性溶液中端基能被氧化。无臭，无味。
Dextran a multi-use, branched glucan with long, hydrophilic spacer arms that improve the performance of immobilized proteins acting on macromolecules. Low molecular weight dextran is useful as a stabilizer, volume extender, lubricant, binding platform, and matrix component. Higher molecular weight dextrans have differing viscosities, aggregation and permeation properties.
Dextran a multi-use, branched glucan with long, hydrophilic spacer arms that improve the performance of immobilized proteins acting on macromolecules. Low molecular weight dextran is useful as a stabilizer, volume extender, lubricant, binding platform, and matrix component. Higher molecular weight dextrans have differing viscosities, aggregation and permeation properties
固体