CAS 9002-04-4 MFCD00082072-Thrombin from human plasma TAO{mole}

Thrombin from human plasma

CAS 9002-04-4 MFCD00082072

化学结构图

SMILES:

化学属性

Mol. Weight	37000(Average)
Solubility	H2O: 1 mL/vial clear to slightly hazy, colorless solution
Appearance	powder
Mol. Formula	N/A

别名和识别编码

Synonym	Thrombin (MW 37kDa) {LY} Thrombin (MW 37kDa) {} {LY} Thrombin (MW 37kDa) {} {} {LY} Thrombin (MW 37kDa) {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (
MDL Number	MFCD00082072
CAS Number	9002-04-4
EC Number	232-648-7
Chemical Name	Thrombin from human plasma
Chemical Name Translation
Merck Number	9346
Canonical SMILES	[Thrombin]

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分类

3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, Proteases, Proteases & Protein Sequencing, Proteases for Recombinant Protein Fusion Tag Cleavage, Proteolytic Enzymes, Proteolytic Enzymes and Substrates, Selective Proteolytic Enzymes, Serum Proteins and Related Enzymes, Serum Related Enzymes, Thrombin
{SNA} 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Analytical and Industrial Enzymes, Application Index, Biochemicals and Reagents, Coagulation Proteins and Reagents, Coagulation/Hematological, Core Bioreagents,
{SNA} 3.4.x.x Peptidases,

安全信息

GHS Symbol

WGK Germany2

Precautionary statements

P342+P311
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Signal word

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
H335 May cause respiratory irritation 可能导致呼吸道刺激

Hazard Codes Xn,Xi Xn,B Xn

RTECSXO8950000

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S24 Avoid contact with skin 避免皮肤接触；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R42 May cause sensitisation by inhalation 吸入会产生过敏反应

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 1,272,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >50 mL/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 28,329,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7771 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 16,669,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >50 mL/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yak

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Bird - chicken Embryo
DOSE/DURATION           : 10 mg/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 72,131,1975

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 5 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 13,1,1992

其他信息

色指数:52000
可燃性危险特性:可燃;燃烧产生有毒氮氧化物,硫氧化物和氯化氢烟雾
储运特性:库房通风低温干燥
急性毒性:腹腔-大鼠LD50: 215 毫克/公斤; 腹腔-小鼠LD50: 400 毫克/公斤
毒性分级:高毒
color:white
下游产品:光致变色聚噻嗪
灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
MOL 文件:581-64-6.mol
图谱信息:劳氏紫 (581-64-6)红外图谱(IR1) 劳氏紫 (581-64-6)红外图谱(IR2) 劳氏紫 (581-64-6)质谱(MS)
类别:有毒物品