CAS 90-33-5 MFCD00006866-7-Hydroxy-4-methyl-2H-chromen-2-one 7-羟基-4-甲基香豆素 TAO{mole}

7-Hydroxy-4-methyl-2H-chromen-2-one 7-羟基-4-甲基香豆素

CAS 90-33-5 MFCD00006866

化学结构图

SMILES: Cc1cc(=O)oc2cc(O)ccc12

化学属性

Mol. Formula	C10H8O3
Mol. Weight	176.17
Density	1.422
Melting Point	188.5-190 °C
Solubility	Soluble in alcohol. Insoluble in cold water
TSCA	Yes
Appearance	针状体结晶。熔点185-186℃（194-195℃）溶于乙醇、乙酸、碱溶液和氨，微溶于热水、乙醚和氯仿。与浓硫酸作用呈蓝色荧光。
Boiling Point	267.77 °C at 760 mmHg

别名和识别编码

Chemical Name	7-Hydroxy-4-methyl-2H-chromen-2-one
CAS Number	90-33-5
Synonym	4-Methylumbelliferone {LY} 4-Methylumbelliferone {} {LY} 4-Methylumbelliferone {} {} {LY} 4-Methylumbelliferone {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylumbelliferone {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number	MFCD00006866
EC Number	201-986-7
Beilstein Registry Number	18,31
PubChem Substance ID	5280567
Merck Number	4854
Chemical Name Translation	7-羟基-4-甲基香豆素
Reaxys-RN	142217
Wiswesser Line Notation	T66 BOVJ E1 IQ
LabNetwork Molecule ID	LN00196075
InChI	InChI=1S/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3
Canonical SMILES	O=C1C=C(C)C2=CC=C(O)C=C2O1

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

适用于做激光染料，荧光测定酶活性的标准。测定硝酸的指示剂。

安全信息

Signal word Warning

GHS Symbol

WGK Germany2

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S37 Wear suitable gloves 戴适当手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P302+P352+P332+P313+P362+P364
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P332+P313
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P305+P351+P338+P337+P313
P302+P350
P337+P313
P305+

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H303 May be harmfully swallowed 吞食可能有害

RTECSGN7000000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn Xi Xi,Xn

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 5,1619,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3850 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 5,1619,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2850 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Sense Organs and Special Senses (Eye) - ptosis
   Beha

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Vol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1500 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 4,403,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 gm/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 4,413,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6 gm/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 4,403,1970

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

方法一:由间苯二酚与乙酰乙酸乙酯经环合反应而得。将浓硫酸冷至10℃以下，于搅拌下滴加由间苯二酚与乙酰乙酸乙酯配成的溶液，滴完后放置12h。然后将反应物投入有碎冰的水中，将析出的沉淀滤出，用稀氢氧化钠溶液及稀硫酸精制而得成品。
图谱信息:4-甲基伞形酮(90-33-5)红外图谱(IR2) 4-甲基伞形酮(90-33-5)质谱(MS) 4-甲基伞形酮(90-33-5)红外图谱(IR1)
上游原料:乙酰乙酸乙酯 --> 稀硫酸 --> 间苯
羟甲香豆素:4-甲基伞形酮又称为羟甲香豆素、胆通，是一种新型利胆药，属香豆素衍生物，常温下为白色或类白色结晶性粉末，无臭，无味。不溶于水，略溶于甲醇、乙醇，易溶于氢氧化钠溶液，对胆道口括约肌有舒张作用，具有较强的解痉、镇痛作用，同时也能温和、持续地促进胆汁分泌，加强胆囊收缩和抑菌作用，具有明显的利胆作用，有利于结石排出，对胆总管结石有一定排石效果。尚可降低肝酶，使之恢复正常。临床主要用于胆囊炎、胆道感染、胆结石、胆道术后综合征。部分原有丙氨酸氨基转移酶升高的患者，服药后随炎症的消除而恢复正常，个别有头晕、腹胀、胸闷、皮疹、腹泻等，停药后自行消失。大剂量可引起胆汁过度分泌与腹泻。梗阻性和传染性黄疸性肝炎者慎用。
4-甲基伞形酮价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 M0453 4-甲基伞形酮 4-Methylumbelliferone 25G 150元 2014/06/02 M0453 4-甲基伞形酮 4-Methylumbelliferone 500G 1450元 2010/06/21 405490250 4-甲基伞形酮 7-Hydroxy-4-methylcoumarin , pure, laser grade 25 GR 294元
用途二:用作医药中间体
TCI Shanghai:4-甲基伞形酮 4-Methylumbelliferone,>;98.0%(T)(90-33-5)
Acros Organics:7-羟基-4-甲基香豆素 7-Hydroxy-4-methylcoumarin, pure, 97%(90-33-5)
用途三:适用于做激光染料，荧光测定酶活性的标准。测定硝酸的指示剂。
Hazard Note:Irritant
color:off-white to yellow
Sigma Aldrich:90-33-5(sigmaaldrich)
微溶于水，溶于浓硫酸溶液，部分溶于5%的Na2CO3溶液，部分溶于乙醇和异丙醇。与浓硫酸作用呈蓝色荧光。
用途一:该品为利胆药，又是抗过敏药色甘酸钠的中间体
MOL 文件:90-33-5.mol
检测方法:HPLC,NMR
Alfa Aesar:4-甲基7－羟基香豆素,97% 4-Methylumbelliferone, 97%(90-33-5)
下游产品:8-乙酰基-7-羟基-4-甲基-2H-1-苯并吡喃-2-酮
MSDS 信息:7-Hydroxy-4-methylcoumarin(90-33-5).msds