KX02 (KX2-361) -（3-氟苄基）-2-（5-（4-吗啉代苯基）吡啶-2-基）乙酰胺
CAS 897016-26-1 MFCD97016261
化学结构图
SMILES: O=C(Cc1ccc(-c2ccc(N3CCOCC3)cc2)cn1)NCc1cccc(F)c1
化学属性
| Mol. Formula | C24H24FN3O2 |
|---|---|
| Mol. Weight | 405.4734 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | -（3-氟苄基）-2-（5-（4-吗啉代苯基）吡啶-2-基）乙酰胺 |
|---|---|
| Chemical Name | KX02 (KX2-361) |
| Formula | C24H24FN3O2 |
| Synonym | KX 2-361; KX2-361; KX-2-361; KX 2361; KX2361; KX-2361; KX 2361; KX 02; KX02; KX-02 |
| IUPAC Name | N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl)acetamide |
| InChIKey | CMKKPJNMYLOUCE-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H24FN3O2/c25-21-3-1-2-18(14-21)16-27-24(29)15-22-7-4-20(17-26-22)19-5-8-23(9-6-19)28-10-12-30-13-11-28/h1-9,14,17H,10-13,15-16H2,(H,27,29) |
| Canonical SMILES | O=C(NCC1=CC=CC(F)=C1)CC2=NC=C(C3=CC=C(N4CCOCC4)C=C3)C=C2 |
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产品应用
- KX02, also known as KX2-361, is a lipophilic, orally available inhibitor of both Src kinase activity and tubulin polymerization, with potential antineoplastic activity. Upon oral administration, src/tubulin inhibitor KX02 binds to and inhibits the activity of Src kinase. This inhibits both downstream signaling and the proliferation of Src kinase-expressing tumor cells. KX02 also binds to tubulin heterodimers and inhibits microtubule polymerization, thereby disrupting microtubule formation, mitosis, and further proliferation.
