Dimethyloxalylglycine 二甲基乙二酰氨基乙酸

CAS 89464-63-1 MFCD05865098

化学结构图

89464-63-1
SMILES: COC(=O)CNC(=O)C(=O)OC

化学属性

Mol. FormulaC6H9NO5
Mol. Weight175
Boiling Point182°C/12mmHg(lit.)
Melting Point49.0 to 53.0 deg-C

别名和识别编码

Chemical NameDimethyloxalylglycine
CAS Number89464-63-1
Alfabeta NameDIMETHYLOXALYLGLYCINE
MDL NumberMFCD05865098
Synonym DMOG Dimethyloxalylglycine N-(Methoxyoxoacetyl)-glycine methyl ester
Chemical Name Translation二甲基乙二酰氨基乙酸
PubChem Substance ID329798774
Reaxys-RN2096268
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分类

  • {SNA} Aerobic Glycolysis (the Warburg Effect), Cancer Metabolism, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators, Gene Regulation and Expression, HIF Prolyl-Hydroxylase Inhibitors, Inhibitors of Aerobic Glycolysis (the Warburg Effect)
  • {SNA} Bioactive Small Molecule Alphabetical Index, DIG-DY, DNA-RNA Transcription Regulators, Gene Regulation and Expression, HIF 脯氨酸羟化酶抑制剂, 有氧糖酵解(Warburg效应), 有氧糖酵解(Warburg效应)抑制剂, 生物活性小分子, 癌症代谢, 癌症研究, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • [2]. Milkiewicz M, et al. Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. J Physiol. 2004 Oct 1;560(Pt 1):21-6.
  • [3]. Schultz K, et al. Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L921-7.
  • [4]. Li X, et al. Up-regulation of hypoxia-inducible factor-1α enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):112-8.
  • [5]. Singh A, et al. Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.Sci Rep. 2020 Jan 31;10(1):1597.
  • [1]. Baader E, et al. Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues.

安全信息

Warnings IRRITANT
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P301+P312+P330

系列性分类


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