CAS 894-71-3 MFCD00058024-Nortriptyline Hydrochloride 盐酸去甲替林 TAO{mole}

Nortriptyline Hydrochloride 盐酸去甲替林

CAS 894-71-3 MFCD00058024

化学结构图

SMILES: CNCCC=C1c2ccccc2CCc2ccccc21.Cl

化学属性

Mol. Formula	C19H21N·HCl
Mol. Weight	299.84
Melting Point	216.0 to 220.0 deg-C

别名和识别编码

Chemical Name	Nortriptyline Hydrochloride
CAS Number	894-71-3
Synonym	3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1- 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine hydrochloride Desmethylamitriptyline hydrochloride 5-(3-(Methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)diene Allegron Apo Nortriptyline Apo-Nortriptyline Aventyl Aventyl allegron Aventyl hydrochloride Desitriptyline Desmethylamitriptylin Desmethylamitriptyline hydrochloride Gen Nortriptyline Gen-Nortriptyline Hydrochloride, Nortriptyline Norfenazin Nortrilen Nortriptyline Nortriptyline Hydrochloride Nortriptyline hydrochloride Novo Nortriptyline Novo-Nortriptyline Nu Nortriptyline Nu-Nortriptyline PMS Nortriptyline PMS-Nortriptyline Pamelor {P
MDL Number	MFCD00058024
PubChem Substance ID	253662334
EC Number	212-973-0
Chemical Name Translation	盐酸去甲替林
Reaxys-RN	4163872
Merck Number	6715
Wiswesser Line Notation	L C676 BY&T&J BU3M1 &GH
LabNetwork Molecule ID	LN01300785
InChI	InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H

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分类

{SNA} Approved Therapeutics/Drug Candidates,
{SNA} Analytical S
{SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors, Eli Lilly, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, N, Neuroscience, Neurotransmission, Neurotransmission (Obesity), Neurotransmitters, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 肥胖研究,
{SNA} Analytical Standards,
{SNA} Analytical St
{SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards N - O, 分析/色谱

产品应用

Tricyclic antidepressant.

安全信息

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

WGK Germany3

Signal word Warning

RTECSHP0175000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S22 Do not breathe dust 不要吸入粉尘；

Hazard Codes Xn

Risk Statements

R22 Harmful if swallowed 吞咽有害

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P312
P301+P312+P330
P330 Rinse mouth. 漱口
P501 Dispose of contents/container to..… 处理内容物/容器.....

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : >75 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   9,152,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 71 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,568,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >75 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   9,152,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,568,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE