Bromoenol lactone
CAS 88070-98-8 MFCD00270871
化学结构图
SMILES: O=C1O/C(/CCC1C1=CC=CC2C=CC=CC=21)=C/Br
化学属性
| Mol. Formula | C16H13BrO2 |
|---|---|
| Mol. Weight | 317.18 |
别名和识别编码
| Chemical Name | Bromoenol lactone |
|---|---|
| Synonym | BEL BEL E-6-(Bromoethylene)tetrahydro-3-(1-naphthyl)-2H-pyran-2-one E-6-(Bromoethylene)tetrahydro-3-(1-naphthyl)-2H-pyran-2-one |
| MDL Number | MFCD00270871 |
| PubChem Substance ID | 24278257 |
| CAS Number | 88070-98-8 |
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分类
- A to C, B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Chymotrypsin, α-, Chymotrypsin, alpha-, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Lipids in Cell Signaling, Phospholipase Inhibitors, Phospholipid Metabolism, Protease Inhibitor Specificity Index, Protease Inhibitors
- {SNA} A to C,
- {SNA} A to C, B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Chymotrypsin, α-, Chymotrypsin, alpha-,
- {SNA} A to C,
相关文献及参考
- [2]. Takuma T, et al. Role of Ca2+-independent phospholipase A2 in exocytosis of amylase from parotid acinar cells. J Biochem. 1997 Jun;121(6):1018-24.
- Ackermann, E.J., Inhibition of macrophage Ca 2+ -independent phospholipase A 2 by bromoenol lactone and trifluoromethyl ketones. J. Biol. Chem. 270 , 445, (1995) 摘要
- Balsinde, J., Dennis, E.A., Bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse P388D1 macrophages. J. Biol. Chem. 271 , 31937, (1996) 摘要
- Daniels, S.B., Haloenol lactones: potent enzyme-activated irreversible inhibitors for α-chymotrypsin. J. Biol. Chem. 258 , 15046, (1983) 摘要
- Hazen. S.L., et al., Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A 2 . J. Biol. Chem. 266 , 7227-7232, (1991) 摘要
- Malhotra, A., et al., Role Of Calcium-independent Phospholipase A2 In The Pathogenesis Of Barth Syndrome. Proc. Natl
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
