RO-3306 2-[[(噻吩-2-基)甲基]氨基]-5-[1-(喹啉-6-基)甲-(Z)-亚基]噻唑-4-酮
CAS 872573-93-8 MFCD72573938
化学结构图
SMILES: O=C1N=C(NCc2cccs2)S/C1=C/c1ccc2ncccc2c1
化学属性
| Mol. Weight | 351.44 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not soluble in water. |
别名和识别编码
| Chemical Name Translation | 2-[[(噻吩-2-基)甲基]氨基]-5-[1-(喹啉-6-基)甲-(Z)-亚基]噻唑-4-酮 |
|---|---|
| Chemical Name | RO-3306 |
| Formula | C18H13N3OS2 |
| Synonym | RO3306; RO 3306; RO-3306 |
| IUPAC Name | 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone |
| InChIKey | XOLMRFUGOINFDQ-MHWRWJLKSA-N |
| InChI | InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10+ |
| Canonical SMILES | O=C1N=C(NCC2=CC=CS2)S/C1=C/C3=CC=C4N=CC=CC4=C3 |
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产品应用
- RO-3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO-3306 induced G2/M-phase cell cycle arrest and apoptosis in a dose- and time-dependent manner. RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2. RO-3306 actively enhances downstream p53 signaling to promote apoptosis.
