Cis-3-(8-Amino-1-(2-Phenylquinolin-7-Yl)Imidazo[1,5-A]Pyrazin-3-Yl)-1-Methylcyclobutan-1-Ol 顺式-3-(8-氨基-1-(2-苯基喹啉-7-基)咪唑并[1,5-a]吡嗪-3-基)-1-甲基环丁醇
CAS 867160-71-2 MFCD12912153
化学结构图
SMILES: C[C@]1(O)C[C@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn32)C1
化学属性
| Mol. Formula | C26H23N5O |
|---|---|
| Mol. Weight | 421.5 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Cis-3-(8-Amino-1-(2-Phenylquinolin-7-Yl)Imidazo[1,5-A]Pyrazin-3-Yl)-1-Methylcyclobutan-1-Ol |
|---|---|
| CAS Number | 867160-71-2 |
| Synonym | OSI 906 OSI 906AA OSI906; OSI-906; OSI 906; Linsitinib. cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol |
| Chemical Name Translation | 顺式-3-(8-氨基-1-(2-苯基喹啉-7-基)咪唑并[1,5-a]吡嗪-3-基)-1-甲基环丁醇 |
| Formula | C26H23N5O |
| IUPAC Name | (1r,3r)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol. |
| InChIKey | PKCDDUHJAFVJJB-KQODVJPSSA-N |
| InChI | InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)/t19-,26- |
| Canonical SMILES | O[C@@]1(C)C[C@H](C2=NC(C3=CC=C4C=CC(C5=CC=CC=C5)=NC4=C3)=C6C(N)=NC=CN62)C1 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Amines
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Tyrosine Kinase Inhibitors
产品应用
- Linsitinib, also known as OSI-906, is a n orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGFR-1 stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.
相关文献及参考
- Mulvihill, M.M.J. et al.: Fut. Med. Chem., 1, 1153 (2009); Flanigan, S.A. et al.: Clin. Cancer Res., 16, 5436 (2010); McKinley, E.T. et al.: Clin. Cancer Res., 17, 3332 (2011);
