Resminostat
CAS 864814-88-0 MFCD64814880
化学结构图
SMILES: CN(C)Cc1ccc(S(=O)(=O)n2ccc(/C=C/C(=O)NO)c2)cc1
化学属性
| Mol. Weight | 349.40476 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| InChIKey | FECGNJPYVFEKOD-VMPITWQZSA-N |
|---|---|
| Chemical Name | Resminostat |
| Chemical Name Translation | |
| Formula | C16H19N3O4S |
| Synonym | 4SC201; 4SC-201; 4SC 201; RAS-2410; RAS2410; RAS 2410; Resminostat. |
| IUPAC Name | (E)-3-(1-((4-((dimethylamino)methyl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-hydroxyacrylamide. |
| InChI | InChI=1S/C16H19N3O4S/c1-18(2)11-13-3-6-15(7-4-13)24(22,23)19-10-9-14(12-19)5-8-16(20)17-21/h3-10,12,21H,11H2,1-2H3,(H,17,20)/b8-5+ |
| Canonical SMILES | O=C(NO)/C=C/C1=CN(S(=O)(C2=CC=C(CN(C)C)C=C2)=O)C=C1 |
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产品应用
- Resminostat, also known as 4S-201 and RAS2410, is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity. Resminostat binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, inhibition of the transcription of tumor suppressor genes, inhibition of tumor cell division and the induction of tumor cell apoptosis.
