STX-0119
CAS 851095-32-4 MFCD51095324
化学结构图
SMILES: O=C(Nc1nnc(-c2ccco2)o1)c1cc(-c2ccccc2)nc2ccccc12
化学属性
| Mol. Weight | 382.37 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | |
|---|---|
| Chemical Name | STX-0119 |
| Formula | C22H14N4O3 |
| Synonym | STX0119; STX 0119; STX0119. |
| IUPAC Name | N-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide |
| InChIKey | MNPXTRXFUMGQLK-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H14N4O3/c27-20(24-22-26-25-21(29-22)19-11-6-12-28-19)16-13-18(14-7-2-1-3-8-14)23-17-10-5-4-9-15(16)17/h1-13H,(H,24,26,27) |
| Canonical SMILES | O=C(C1=CC(C2=CC=CC=C2)=NC3=CC=CC=C13)NC4=NN=C(C5=CC=CO5)O4 |
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产品应用
- STX-0119 is a potent STAT3 inhibitor. STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors, and could be the next promising compound leading to survival prolongation. STX-0119 demonstrated strong inhibition of the expression of STAT3 target genes (c-myc, survivin, cyclin D1, HIF-1α and VEGF) and stem cell-associated genes (CD44, Nanog, nestin and CD133) as well as the induction of apoptosis in one stem-like cell line.
