N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine N-[[6-甲氧基-5-(三氟甲基)-1-萘基]硫代甲基]-N-甲基甘氨酸
CAS 82964-04-3 MFCD00864170
化学结构图
SMILES: COc1ccc2c(C(=S)N(C)CC(=O)O)cccc2c1C(F)(F)F
化学属性
| Mol. Formula | C16H14F3NO3S |
|---|---|
| Mol. Weight | 357.351 |
别名和识别编码
| Chemical Name | N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine |
|---|---|
| Chemical Name Translation | N-[[6-甲氧基-5-(三氟甲基)-1-萘基]硫代甲基]-N-甲基甘氨酸 |
| LabNetwork Molecule ID | LN01312347 |
| PubChem Substance ID | 53359 |
| InChI | InChI=1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22) |
| Synonym | AY 27773 AY-27,773 N-((5-(trifluoromethyl)-6-methoxy-1-naphthalenyl)thioxomethyl)-N-methylglycine N-5-trifluoromethyl-6-methoxy-1-thionaphthoyl-N-methylglycine tolrestat |
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相关文献及参考
- [2]. Simard-Duquesne N, et al. The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats. Metabolism. 1985 Oct;34(10):885-92.
- [3]. Srivastava S, et al. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 9;105(8):793-802.
- [1]. Sestanj K, et al. N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor. J Med Chem. 1984 Mar;27(3):255-6.
- [1]. Sestanj K, et al. N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor. J Med Chem. 1984 Mar;27(3):255-6.
- [2]. Simard-Duquesne N, et al. The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats. Metabolism. 1985 Oct;34(10):885-92.
- [3]. Srivastava S, et al. Aldose reductase protects agai
