(2S,3As,7As)-1-((S)-2-(((S)-1-Ethoxy-1-Oxopentan-2-Yl)Amino)Propanoyl)Octahydro-1H-Indole-2-Carboxylic Acid (2S,3aS,7aS)-1-((S)-2-(((S)-1-乙氧基-1-氧代戊-2-基)氨基)丙酰基)八氢-1H-吲哚-2-羧酸

CAS 82834-16-0 MFCD82834160

化学结构图

82834-16-0
SMILES: CCOC(=O)[C@H](CCC)N[13C@@H]([13CH3])[13C](=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(O)=O

化学属性

Mol. Weight368.53
Mol. FormulaC19H32N2O5

别名和识别编码

CAS Number82834-16-0
Chemical Name(2S,3As,7As)-1-((S)-2-(((S)-1-Ethoxy-1-Oxopentan-2-Yl)Amino)Propanoyl)Octahydro-1H-Indole-2-Carboxylic Acid
Synonym [2S-[1[R*(R*)],2?,3a?,7a?]]- Perindopril McN-A 2833 (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid S-9490
Beilstein Registry Number4300272
Chemical Name Translation(2S,3aS,7aS)-1-((S)-2-(((S)-1-乙氧基-1-氧代戊-2-基)氨基)丙酰基)八氢-1H-吲哚-2-羧酸
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分类

  • Amines
  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • An angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.

相关文献及参考

  • [2]. Napalkov DA. Therapy with perindopril: organoprotection, not just the antihypertensive effect. Kardiologiia. 2012;52(12):80-3.
  • Lees, K.R., et al.: Brit. J. Clin. Pharmacol., 23, 159 (1987),
  • [1]. Vaclavik J, Perindopril in the treatment of hypertension and cardiovascular diseases: evolution continues with the orodispersible dosage form. Vnitr Lek. 2013 Apr;59(4):290-4.
  • [1]. Vaclavik J, Perindopril in the treatment of hypertension and cardiovascular diseases: evolution continues with the orodispersible dosage form. Vnitr Lek. 2013 Apr;59(4):290-4.
  • [2]. Napalkov DA. Therapy with perindopril: organoprotection, not just the antihypertensive effect. Kardiologiia. 2012;52(12):80-3.

安全信息

RTECSNL5999400 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 22,1673,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,446,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 pe

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 22,1679,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,446,1992

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TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 416 mg/kg
SEX/DURATION            : female 17-21 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 22,1729,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1010 mg/kg
SEX/DURATION            : male 80 day(s) pre-mating
                          female 2 week(s) pre-mating  - 7 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 22,1729,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 192 mg/kg
SEX/DURATION            : female 6-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeut

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Angiotensin-converting Enzyme (ACE)  (血管紧张素转换酶)

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