Idronoxil, also known as Phenoxodiol, is a synthetic flavonoid derivative. Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.
CAS 81267-65-4 MFCD06636630
化学结构图
SMILES: Oc1ccc(C2=Cc3ccc(O)cc3OC2)cc1
化学属性
| Mol. Formula | C15H12O3 |
|---|---|
| Mol. Weight | 240.25398 |
| Appearance | Off-white to light brown |
| Solubility | soluble in DMSO, not soluble in water. |
别名和识别编码
| Chemical Name | Idronoxil, also known as Phenoxodiol, is a synthetic flavonoid derivative. Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death. |
|---|---|
| Synonym | 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol Dehydroequol Haginin E Idronoxil NV 06 NV-06; NV06; NV 06; Dehydroequol; Idronoxil; Phenoxodiol; Haginin E. Phenoxodiol |
| MDL Number | MFCD06636630 |
| PubChem Substance ID | 329798852 |
| Formula | C15H12O3 |
| IUPAC Name | 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol |
| InChIKey | ZZUBHVMHNVYXRR-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H12O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-8,16-17H,9H2 |
| Canonical SMILES | OC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1 |
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分类
- {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, P-PH, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience
产品应用
- Idronoxil, also known as Phenoxodiol, is a synthetic flavonoid derivative. Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.
安全信息
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
GHS Symbol
- P273 Avoid release to the environment. 避免释放到环境中。
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H302 Harmful if swallowed 吞食有害
- R50 Very toxic to aquatic organisms 对水生生物极毒
- R22 Harmful if swallowed 吞咽有害
