3?-Hydroxy Pravastatin Sodium Salt
CAS 81093-43-8 MFCD81093438
化学结构图
SMILES: [Na+].CC[C@H](C)C(=O)O[C@H]1CC=CC2=C[C@@H](O)[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@H]21
化学属性
| Mol. Weight | 446.51 |
|---|---|
| Mol. Formula | C23H35NaO7 |
别名和识别编码
| CAS Number | 81093-43-8 |
|---|---|
| Chemical Name | 3?-Hydroxy Pravastatin Sodium Salt |
| Synonym | (?R,?R,1S,2R,3S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-?,?,3-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic Acid Sodium Salt |
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分类
- Chiral Reagents
- Metabolites & Impurities
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A metabolite of Pravastatin, a competitive inhibitor of HMG-CoA reductase. Bioactive metabolite of mevastatin.
相关文献及参考
- [2]. Shiomi M, et al. Pravastatin sodium, a competitive inhibitor of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly secreted very-low-density lipoprotein in Watanabe heritable hyperlipidemic rabbits. Metabolism. 1994;43(5):559‐564.
- Serizawa, N., et al.: J. Antibiot., 36, 604 (1983),
- [1]. Zhang X, Vernikovskaya DI, Wang X, et al. Quantitative determination of pravastatin and its metabolite 3α-hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS. Biomed Chromatogr. 2016;30(4):548‐554.
- [1]. Zhang X, Vernikovskaya DI, Wang X, et al. Quantitative determination of pravastatin and its metabolite 3α-hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS. Biomed Chromatogr. 2016;30(4):548‐554.
- [2]. Shiomi M, et al. Pravastatin sodium, a competitive inhibitor of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly secret
