CAS 80-11-5 MFCD00002050-N-Methyl-N-nitrosotoluene-4-sulphonamide N-甲基-N-亚硝基对甲苯磺酰胺 TAO{mole}

N-Methyl-N-nitrosotoluene-4-sulphonamide N-甲基-N-亚硝基对甲苯磺酰胺

CAS 80-11-5 MFCD00002050

化学结构图

SMILES: Cc1ccc(S(=O)(=O)N(C)N=O)cc1

化学属性

Mol. Formula	C8 H10 N2 O3 S
Mol. Weight	214.24
Melting Point	60-63°C
Appearance	黄色结晶。熔点62℃。溶于醚、苯、氯仿、甲氯化碳，不溶于水。
Boiling Point
Flash Point	-

别名和识别编码

Chemical Name	N-Methyl-N-nitrosotoluene-4-sulphonamide
Synonym	Benzenesulfonamide, N,4-dimethyl-N-nitroso- Benzenesulfonamide,N,4-dimethyl-N-nitroso- DIAZALD DIAZALD(R) DIAZOGEN DIAZOMETHANE PRECURSOR Diazald {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Beilstein Registry Number	11(1)29
PubChem Substance ID	24893716
CAS Number	80-11-5
EC Number	201-252-6
MDL Number	-
Chemical Name Translation	N-甲基-N-亚硝基对甲苯磺酰胺
Merck Number	9543
Reaxys-RN	2214345
Wiswesser Line Notation	ONN1&SWR D1
LabNetwork Molecule ID	LN00195443
Canonical SMILES	-

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分类

{SNA} Alkyl Transfer, Alkylation Reagents, Analytical Reagents, Analytical/Chromatography, C-X Bond Formation (Non-Halogen), Chemical Synthesis, Derivatization Reagents, Derivatization Reagents GC,
Alkyl Transfer, Alkylation Reagents, Analytical Reagents, Analytical/Chromatography, C-X Bond Formation (Non-Halogen), Chemical Synthesis, Derivatization Reagents, Derivatization Reagents GC, Derivatization Reagents HPLC, Diazald, Diazoalkales, Greener Alternatives and Technologies, Greener Alternatives: Reagents, Reagents for Alkylation & Esterification, Synthetic Reagents, UV-VIS

安全信息

Precautionary statements

P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P501 Dispose of contents/container to..… 处理内容物/容器.....
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P332+P313
P302+P350
P337+P313
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P302+P352+P332+P313+P362+P364
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P220 Keep/Store away from clothing/…/combustible materials. 保持远离/贮存远离服装/....../可燃材料。
P403+P235
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P420 Store away from other materials. 远离其他材料。
P305+P351+P338+P337+P313
P234 Keep only in original container. 只保留在原来的容器中。

WGK Germany2

GHS Symbol

Signal word Danger

Hazard statements

H242 Heating may cause a fire 加热可能会引起火灾
H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Hazard Codes E,Xi

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSXT5950000

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S15 Keep away from heat 远离热源；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S35 This material and its container must be disposed of in a safe way 该物料及其容器必须以安全方式处置；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R2 Risk of explosion by shock, friction, fire or other sources of ignition 遇到震动、摩擦、火焰或者其它引燃物有爆炸危险

Packing GroupIII

Hazard Class4.1

Storage condition -20 -20°C -20°C, Inert atmosphere, Light sensitive 0-10 0-10°C 2-8°C

UN Number 3224 UN 3234 4.1/PG 2

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   30,11,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   30,11,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   48,165,1961

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 14 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,11,1981

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,11,1981

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 2330 umol/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 144,177,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 14 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,11,1981

其他信息

用途一:可用于制重氮甲烷，其性质明显优于其它用来制备重氮甲烷的亚硝基化合物
上游原料:4-甲苯磺酰氯
用途四:用于制备重氮甲烷(diazomethane)的前体物质。用于转移金属复合物、氨基、负碳离子等的亚硝基化试剂。
N-甲基-N-亚硝基对甲苯磺酰胺价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 T0323 N-甲基-N-亚硝基对甲苯磺酰胺[重氮甲烷的前体] N-Methyl-N-nitroso-p-toluenesulfonamide [Precursor to Diazomethane] 500G 2860元 2014/06/02 T0323 N-甲基-N-亚硝基对甲苯磺酰胺[重氮甲烷的前体] N-Methyl-N-nitroso-p-toluenesulfonamide [Precursor to Diazomethane] 25G 343元
用途二:可用于制重氮甲烷，其性质明显优于其他用来制备重氮甲烷的亚硝基化合物
下游产品:2-(7-羟基苯并呋喃-3-基)乙酸甲酯 --> 7-甲氧基-3(2H)-苯并呋喃酮
用途三:用于制备重氮甲烷。
方法一:将N-甲基对甲苯磺酰胺溶于冰乙酸，冷至5℃，滴加亚硝酸钠水溶液，反应析出呈黄色的N-甲基-N-亚硝基对甲苯磺酰胺。N-甲基对甲苯磺酰胺是由对甲苯磺酰氯与甲胺反应得到的。
Sigma Aldrich:80-11-5(sigmaaldrich)
MSDS 信息:Diazald(80-11-5).msds
图谱信息:N-甲基-N-亚硝基对甲苯磺酰胺(80-11-5)质谱(MS) N-甲基-N-亚硝基对甲苯磺酰胺(80-11-5)核磁图( 13 CNMR) N-甲基-N-亚硝基对甲苯磺酰胺(80-11-5)红外图谱(IR1) N-甲基-N-亚硝基对甲苯磺酰胺(80-11-5)核磁图( 1 HNMR)
MOL 文件:80-11-5.mol