1-(4-(3-Amino-1H-Indazol-4-Yl)Phenyl)-3-(2-Fluoro-5-Methylphenyl)Urea 1-(4-(3-氨基-1H-吲唑-4-基)苯基)-3-(2-氟-5-甲基苯基)脲
CAS 796967-16-3 MFCD11840918
化学结构图
SMILES: Cc1ccc(F)c(N(C(N)=O)c2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1
化学属性
| Mol. Formula | C21H18FN5O |
|---|---|
| Mol. Weight | 375 |
| Appearance | Solid powder |
| Solubility | soluble in DMSO, not soluble in water. |
别名和识别编码
| Chemical Name | 1-(4-(3-Amino-1H-Indazol-4-Yl)Phenyl)-3-(2-Fluoro-5-Methylphenyl)Urea |
|---|---|
| CAS Number | 796967-16-3 |
| Synonym | A 741439 A-741439 A741439 ABT 869 ABT-869 ABT869 ABT869; ABT 869; ABT-869; Linifanib N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea RG 3635 RG-3635 RG3635 linifanib |
| Chemical Name Translation | 1-(4-(3-氨基-1H-吲唑-4-基)苯基)-3-(2-氟-5-甲基苯基)脲 |
| PubChem Substance ID | 11485656 |
| InChI | InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)27(21(24)28)14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)26-25-17/h2-11H,1H3,(H2,24,28)(H3,23,25,26) |
| LabNetwork Molecule ID | LN01288485 |
| Formula | C21H18FN5O |
| IUPAC Name | N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N1-(2-fluoro-5-methylphenyl) urea |
| InChIKey | ACPCMBPQKQTAQY-UHFFFAOYSA-N |
| Canonical SMILES | O=C(N)N(C1=CC=C(C2=CC=CC3=C2C(N)=NN3)C=C1)C4=CC(C)=CC=C4F |
| MDL Number |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Aromatics
- Heterocycles
- Tyrosine Kinase Inhibitors
产品应用
- Linifanib, also known as ABT-869, is an orally bioavailable, small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as fms-related tyrosine kinase receptor-3 (FLT3).
相关文献及参考
- Haddley, K., et al.: Drugs of the Future, 35, 106 (2010),
- Cheng, A., et al.: J. Med. Chem., 53, 4502 (2010),
安全信息
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P308+P313
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
