Retinol Palmitate 视黄醇棕榈酸酯

CAS 79-81-2 MFCD00019414

化学结构图

79-81-2
SMILES: CCCCCCCCCCCCCCCC(=O)OC/C=C(C)\C=C\C=C(C)/C=C/C1=C(C)CCCC1(C)C

化学属性

Mol. FormulaC36H60O2
Mol. Weight525
Appearance oil
Melting Point28-29

别名和识别编码

Chemical NameRetinol Palmitate
MDL NumberMFCD00019414
CAS Number79-81-2
Synonym 3,7-Dime ALL TRANS-RETINOL PALMITATE AROVIT Optovit-A RETINOL PALMITATE RETINOL PALMITATE ALL TRANS ISOMER RETINOL PALMITATE TYPE IV: ALL TRANS RETINOL PALMITATE TYPE VI RETINOL PALMITATE, 100MG, NEAT RETINYL PALMITATE Retinol palmitate Retinol, hexadecanoate Retinyl palmitate Retinyl palmitate all-trans-Retinol palmitate 维生素 A 棕榈酸酯 VITAMIN A PALMITATE VITAMINE A PALMITATE Vitamin A palmitate all-trans-Retinol palmitate 维生素 A 棕榈酸酯 all-trans-retinopalmitate retinol palmitate type iv sigma grade retinol,hexadecanoate 维生素 A 棕榈酸酯 维生素A棕榈酸酯 维生素A棕榈酸酯 1.7MLU/G 视黄醇棕榈酸酯
Beilstein Registry Number1917366
EC Number201-228-5
PubChem Substance ID5280531
Chemical Name Translation视黄醇棕榈酸酯
Merck Number13,10073
Wiswesser Line NotationL6UTJ A1 B1U1Y1&U2U1Y1&U2OV15 C1 C1
LabNetwork Molecule IDLN01313031
InChIInChI=1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
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分类

  • {SNA} Nutrition Research, Vitamin A,
  • {SNA} Vitamin A, Vitamins, 细胞生物学, 营养研究
  • {SNA} Additional Standards, Analytical Standards, Chromatography, Pharmaceutical Secondary Standards, Ph
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
  • {SNA} Nutrition Research, Vitamin A, Vitamins
  • {SNA} Vitamin A, Vitamins, 生化试剂
  • {SNA} Additional Standards, Analytical Standards, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards, Pharmacopeia Metrological Institutes Standards, Secondary Standards,

产品应用

  • 维生素类药。

相关文献及参考

  • Merck: 14,10013
  • Merck: 14,10013 Beilstein: 6,IV,4135
  • [1]. Oliveira MB, et al. Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging. Biomed Res Int. 2014;2014:632570.

安全信息

WGK Germany2
RTECSVH6860000
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P405 Store locked up. 上锁保管。
  • P501a
Hazard statements
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
Signal word Danger
GHS Symbol
Safety Statements
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Hazard Codes T Xn T,Xn
Risk Statements
  • R53 May cause long-term adverse effects in the aquatic environment 对水生环境有长期的有害作用
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
Storage condition 储存温度 2-8°C 2-8°C
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6060 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAADDB Journal of the American Academy of Dermatology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63141)  1979-
   Volume(issue)/page/year: 6,652,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7910 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAADDB Journal of the American Academy of Dermatology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63141)  1979-
   Volume(issue)/page/year: 6,652,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4760 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 25(12),84,1979

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 27500 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 58,317,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 36 mg/kg
SEX/DURATION            : male 26 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   AMPLAO AMA Archives of Pathology.  (Chicago, IL)  V.50(4)-69, 1950-60.  For
   publisher information, see APLMAS.  Volume(issue)/page/year: 56,333,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 13750 ug/kg
SEX/DURATION            : female 35 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 50,223,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 248 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 144,429,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 275 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   IDZAAW Japanese Jou

其他信息

  • MOL 文件:79-81-2.mol
  • 用途一:能透皮吸收,抗角质化,刺激胶原蛋白和弹性蛋白的生长,增加表皮及真皮的厚度。增强皮肤弹性,有效消除皱纹,促进皮肤更新,保持皮肤活力。用于眼霜、保湿霜、修护霜、香波、护发素等
  • 用途三:维生素类药。
  • 图谱信息:维生素 A 棕榈酸酯(79-81-2)红外图谱(IR1) 维生素 A 棕榈酸酯(79-81-2)质谱(MS)
  • 维生素 A 棕榈酸酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 K9515001 维生素A棕榈酸酯(+4℃) 25g 296元
  • Sigma Aldrich:79-81-2(sigmaaldrich)
  • 溶于乙醇,易溶于乙醚、三氯甲烷、丙酮和油酯中
  • F:8-10-23
  • 用途二:属维生素类药
  • 外观性质:淡黄色结晶或油溶液,溶于乙醇,易溶于乙醚、三氯甲烷、丙酮和油酯中熔点:28~29℃

系列性分类


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