CAS 78415-72-2 MFCD00133539-Milrinone 米利酮 TAO{mole}

Milrinone 米利酮

CAS 78415-72-2 MFCD00133539

化学结构图

SMILES: CC1NC(=O)C(=CC=1C1C=CN=CC=1)C#N

化学属性

Mol. Formula	C12H9N3O
Mol. Weight	211
TSCA	No
Melting Point	264°
Density	1.422

别名和识别编码

Chemical Name	Milrinone
CAS Number	78415-72-2
Synonym	1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile Win 47203 Corotrope WIN 47203 Milrinone YM 018 Milrila
MDL Number	MFCD00133539
PubChem Substance ID	87577949
EC Number	278-903-6
Alfabeta Name	METHYLOXODIHYDROBIPYRIDINECARBONITRILEMILRINONE 2616345()---------,,'
Merck Number	6197
Beilstein Registry Number	3546821
Reaxys-RN	3546821
Chemical Name Translation	米利酮

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

Selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic.

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H301 Toxic if swallowed 吞食有毒
H311 Toxic in contact with skin 皮肤接触中毒
H331 Toxic if inhaled 吸入中毒

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

RTECSDW1762000

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P310+P330
P305+P351+P338
P305+P351+P338+P337+P313
P332+P313
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Warnings IRRITANT

Safety Statements

Hazard Codes T

Risk Statements

R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒

Packing GroupIII

UN Number 2811

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
D

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 73 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,245,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 58 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 27,652,1996

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >25 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - other changes
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Toky

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 44400 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Cardiac - cardiomyopathy including infarction
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY

Hazard Class6.1