GNF-2 GNF-2

CAS 778270-11-4 MFCD09265253

化学结构图

778270-11-4
SMILES: NC(=O)c1cccc(-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)c1

化学属性

Mol. FormulaC18H13F3N4O2
Mol. Weight374.32
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameGNF-2
Synonym 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-2 GNF2; GNF-2; GNF 2.
MDL NumberMFCD09265253
PubChem Substance ID24724498
CAS Number778270-11-4
FormulaC18H13F3N4O2
IUPAC Name3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide
InChIKeyWEVYNIUIFUYDGI-UHFFFAOYSA-N
InChIInChI=1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)
Canonical SMILESO=C(N)C1=CC=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=C1
Chemical Name TranslationGNF-2
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分类

  • {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, G, Kinase/Phosphatase Biology, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors, c-Abl, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G, Kinase/Phosphatase Biology, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors, c-Abl
  • {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology,

产品应用

  • GNF-2 is an allosteric inhibitor of Bcr-abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-abl-expressing cells. Selective for Bcr-abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.

相关文献及参考

  • Adrian, F.J., et al. , Allosteric inhibitors of Bcr-abl-dependent cell proliferation Nature Chem. Biol. 2 , 95-102, (2006) 摘要
  • Ohren, J.F. and Sebolt-Leopold, J.S., Inhibitors of Bcr-abl... breaking new ground again Nature Chem. Biol. 2nd ed.,, 63-64, (2006) 摘要

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Apoptosis Inhibitors - Apoptosis and Cell Cycle
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Non-Receptor Tyrosine Kinase Biology - Kinase/Phosphatase Biology
  6. Non-Receptor Tyrosine Kinase Inhibitors - Non-Receptor Tyrosine Kinase Biology
  7. c-Abl - Non-Receptor Tyrosine Kinase Inhibitors
  1. Medical Research Areas
  2. Angiogenesis
  3. Bcr-Abl
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Bcr-Abl

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