HISTRELIN
CAS 76712-82-8 MFCD00133494
化学结构图
SMILES: CC(C)C[C@H](NC(=O)[C@@H](CC1=CN(CC2C=CC=CC=2)C=N1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2C=CC=CC=21)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC
化学属性
| Mol. Formula | C66H86N18O12 |
|---|---|
| Mol. Weight | 1323.50 |
别名和识别编码
| Chemical Name | [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide |
|---|---|
| Synonym | Histrelin ((ImBl)-D-His(sub 6),Pro(sub 9)-NEt)LHRH ORF 17070 |
| MDL Number | MFCD00133494 |
| PubChem Substance ID | 24896325 |
| CAS Number | 76712-82-8 |
| Beilstein Registry Number | 4290557 |
信息真实价格透明
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
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分类
- Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors
- {SNA} LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors
相关文献及参考
- Lecomte, P., et al., The antiandrogenic action of gonadotropin-releasing hormone and its agonists on the mouse kidney. Endocrinology 110 , 1-6, (1982) 摘要
- McCreery, B.R., et al., Actions of agonistic and antagonistic analogs of gonadotropin releasing hormone (Gn-RH) in the bullfrog Rana catesbeiana . Gen. Comp. Endocrinol. 46 , 511-520, (1982) 摘要
- Sundaram, K., et al., Inhibition of the action of sex steroids by gonadotropin-releasing hormone (GnRH) agonists: a new biological effect. Life Sci. 28 , 83-88, (1981) 摘要
- Merck 14 ,4722
安全信息
GHS Symbol
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 2333 ug/kg SEX/DURATION : male 4 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 7,140,1986
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 46 ug/kg SEX/DURATION : male 2 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male REFERENCE : JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 7,140,1986
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 4667 ug/kg SEX/DURATION : male 8 week(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 7,140,1986
- R60 May impair fertility 可能降低生殖能力
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S22 Do not breathe dust 不要吸入粉尘；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
