(S)-1-((S)-6-Amino-2-(((S)-1-Carboxy-3-Phenylpropyl)Amino)Hexanoyl)Pyrrolidine-2-Carboxylic Acid N-{N-[(S)-1-羧基-3-苯丙基]-L-赖氨酰}-L-脯氨酸
CAS 76547-98-3 MFCD76547983
化学结构图
SMILES:
化学属性
| Mol. Weight | 405.55 |
|---|---|
| Mol. Formula | C21H31N3O5 |
别名和识别编码
| Chemical Name | (S)-1-((S)-6-Amino-2-(((S)-1-Carboxy-3-Phenylpropyl)Amino)Hexanoyl)Pyrrolidine-2-Carboxylic Acid |
|---|---|
| Synonym | Zestril Lysinopril MK 0521 Lisinopril Prinivil MK 521 (S)-1-(N(sup 2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline MK 522 |
| Beilstein Registry Number | 4276619 |
| CAS Number | 76547-98-3 |
| Chemical Name Translation | N-{N-[(S)-1-羧基-3-苯丙基]-L-赖氨酰}-L-脯氨酸 |
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相关文献及参考
- [2]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24.
- [1]. Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54.
- [1]. Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54.
- [2]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24.
安全信息
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 43 mg/kg/43W-I TOXIC EFFECTS : Cardiac - pulse rate Gastrointestin
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >8500 mg/kg TOXIC EFFECTS : Gastrointestinal - changes in structure or function of salivary glands REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 1200 ug/kg/16D-I TOXIC EFFECTS : Blood - aplastic anemia REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 346,247,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 38,1,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >8500 mg/kg TOXIC EFFECTS : Skin and Appendages - dermatitis, other (after systemic exposure) Skin and Appendages - hair REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,2273,1989
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES
