CAS 76-75-5 MFCD00057564-Thiopental Thiopental TAO{mole}

Thiopental Thiopental

CAS 76-75-5 MFCD00057564

化学结构图

SMILES: CCCC(C)C1(CC)C(=O)NC(=S)NC1=O

化学属性

Mol. Formula	C11H18N2O2S
Mol. Weight	242
Melting Point	158-160°C

别名和识别编码

Chemical Name	United States Pharmacopeia (USP) Reference Standard Thiopental
CAS Number	76-75-5
Synonym	{uni_hamburg} 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid Pentothal (+/-)-THIOPENTAL Penthiobarbital Pentothiobarbital Thiopentobarbital Intraval Thionembutal 5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione 4,6,(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- Tiopentale thiopentobarbital thiopental Thiothal 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid Thiopentone pentothiobarbital Nesdonal Thiopental (±)-Thiopental 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid Pentothal Thiomebumal Pentothal 5-ethyl-5-(1-methylbutyl)-2-thiobarbituric acid
PubChem Substance ID	3000715
EC Number	200-984-3
MDL Number	MFCD00057564
Chemical Name Translation	Thiopental
Wiswesser Line Notation	T6VMYMV FHJ CUS FY3&1 F2
Beilstein Registry Number	0209361
InChI	InChI=1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)

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产品应用

A thio-derivative of Barbituric acid. Controlled substance (depressant). Anesthetic.

安全信息

GHS Symbol

WGK Germany3

Hazard Codes Xn

Hazard statements

H302 Harmful if swallowed 吞食有害

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Precautionary statements

P301+P310
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Signal word Warning

RTECSCQ6300000

Packing GroupIII

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Storage condition 2-8°C

Hazard Class6.1(b)

Risk Statements

R22 Harmful if swallowed 吞咽有害

UN Number UN 1230 3/PG 2

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,260,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHTXA6 Pharmacology and Toxicology.  English translation of FATOAO.  (New
   York, NY)  V.20-22, 1957-59.  Discontinued.  Volume(issue)/page/year:
   20,569,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 1,215,1946

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FSTEAI Farmaco. Scienza e Tecnica.  (Pavia, Italy)  V.1-7, 1946-52.  For
   publisher information, see FRPSAX.  Volume(issue)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent -

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 1500 mg/L
REFERENCE :
   TGANAK Tsitologiya i Genetika.  Cytology and Genetics.  For English
   translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-    1967-  Volume(issue)/page/year: 18(1),13,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1020 mg/kg
SEX/DURATION            : female 1-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   REANBJ Revista Espanola de Anestesiologia y Reanimacion.  (Barcellona,
   Spain)  V.1-12, 1954-65.  Volume(issue)/page/year: 26,137,1979

其他信息

MOL 文件:76-75-5.mol
Sigma Aldrich:76-75-5(sigmaaldrich)