4-Hydroxynonenal 4-羟基壬烯醛
CAS 75899-68-2 MFCD75899682
化学结构图
SMILES: [2H]C([2H])([2H])CCCCC(O)/C=C/C=O
化学属性
| Mol. Weight | 156.25 |
|---|---|
| Mol. Formula | C9H16O2 |
别名和识别编码
| Chemical Name | 4-Hydroxynonenal |
|---|---|
| CAS Number | 75899-68-2 |
| Wiswesser Line Notation | VH1U1YQ5 |
| Synonym | 4-Hydroxy-2-nonenal 4-Hydroxynonenal |
| Chemical Name Translation | 4-羟基壬烯醛 |
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相关文献及参考
- [2]. Csala M, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015 May;1852(5):826-38.
- [3]. Bhowmick S, et al. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl). 2019 Nov 22.
- [1]. Zhong H, et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193-9.
- [1]. Zhong H, et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193-9.
- [2]. Csala M, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015 May;1852(5):826-38.
- [3]. Bhowmick S, et al. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl). 2019 Nov 22.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 69 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZolH## Personal Communication from H. Zollner, Institut fur Biochemie, Der Universitat, Gras, Oct. 23, 1975 Volume(issue)/page/year: 23OCT1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Behavioral - fluid intake Blood - changes in cell count (unspecified) Nutritional and Gross Metabolic - metabolic acidosis REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,100,1984
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 293,1,1992
TYPE OF TEST : Sister chromatid ex
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - guinea pig Cells - not otherwise specified DOSE/DURATION : 100 umol/L REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 52,233,1984
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - guinea pig Cells - not otherwise specified DOSE/DURATION : 100 umol/L REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 52,233,1984
TYPE OF TEST : Micronucleus test TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 1 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 238,223,1990
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 45 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,169,1987
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 60 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Sc
