17-Allylaminogeldanamycin 替拉替尼
CAS 75747-14-7 MFCD04973892
化学结构图
SMILES: CC1=C[C@H](C)[C@@H](O)[C@H](C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(C)=CC=C[C@H](OC)[C@H]1OC(N)=O)C2=O)OC |c:1,28,t:26|
化学属性
| Mol. Formula | C31 |
|---|---|
| Mol. Weight | 586 |
别名和识别编码
| Chemical Name | 17-Allylaminogeldanamycin |
|---|---|
| CAS Number | 75747-14-7 |
| Synonym | 17-Demethoxy-17-allylaminogeldanamycin 17-(Allylamino)-17-demethoxygeldanamycin 17-AAG 17AAG CP 127374 17-Demethoxy-17-(2-propenylamino)geldanamycin 17-(Allylamino)-17-desmethylgeldanamycin |
| MDL Number | MFCD04973892 |
| Chemical Name Translation | 替拉替尼 |
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分类
- {SNA} A-AM, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antitumor Agents, Apoptosis Inducers, Apoptosis and Cell Cycle, Benzenoids, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, HSP-90 Inhibitors, Inhibits an Enzyme, Mechanism of Action
- Inhibitors
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Amines
- {SNA} A-AM, Antibiotics A to Z, Antibiotics A-F, Antitumor Agents, Apoptosis Inducers, Apoptosis and Cell Cycle, Benzenoids, Bioactive Small Molecule Alphabetical Index,
产品应用
- Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic prote
相关文献及参考
- [2]. Raja, Srikumar M., et al. 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells. Cancer Biology & Therapy (2008), 7(10), 163
- [3]. Zhang J, et al. The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cells.Clin Exp Med. 2012 Sep 7.
- [4]. Newman B, et al. HSP90 Inhibitor 17-AAG Selectively Eradicates Lymphoma Stem Cells.Cancer Res. 2012 Sep 1;72(17):4551-61. Epub 2012 Jun 29.
- [5]. Kamal A, et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature. 2003 Sep 25;425(6956):407-10.
- [6]. Enomoto A, et al. The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition. Eur J Cancer. 2013 Nov;49(16):3547-58.
- Basso, A.D., et al.: Oncogene, 21, 1159 (2002),
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