2,2,2-Tribromoethanol 2,2,2-三溴乙醇

CAS 75-80-9 MFCD00004671

化学结构图

75-80-9
SMILES: OCC(Br)(Br)Br

化学属性

Mol. FormulaC2H3Br3O
Mol. Weight282.76 g/mol
Boiling Point94°C/11mmHg(lit.)
Melting Point79.0 to 83.0 deg-C
TSCAYes
Flash Point92-93°C/10mm
Appearance 白色晶体粉末。

别名和识别编码

Chemical Name2,2,2-Tribromoethanol
MDL NumberMFCD00004671
CAS Number75-80-9
Synonym 2,2,2-Tribromoethanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID87577184
Beilstein Registry Number1(3)1362
EC Number200-903-1
Reaxys-RN1733249
Chemical Name Translation2,2,2-三溴乙醇
Wiswesser Line NotationQ1XEEE
LabNetwork Molecule IDLN00195396
InChIInChI=1S/C2H3Br3O/c3-2(4,5)1-6/h6H,1H2
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分类

  • {SNA} Alcohols, Building Blocks, C2 to C6, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds

相关文献及参考

  • Carboxyl groups can be protected as tribromoethyl esters, e.g. by reaction of the acid chloride in the presence of N,N-dimethylaniline. The group is readily cleaved with Zn/AcOH: J. Chem. Soc., Pekin 1., 2875 (1993); (cf. 2,2,2-Trichloroethanol, L08163). The group has also been exploited in the activation of carboxylic acids for amidation with amines, by reductive cleavage of the tribromoethyl ester with a P(III) reagent, preferably Hexamethyl­phosphorous triamide, A12571, and triethylamine. In an analogous esterification method with alcohols, tributylphosphine - DMAP was the preferred system: J. Org. Chem., 64, 1430 (1999).

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSKM3675000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Storage condition Light Sensitive
Hazard Codes Xn
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 63,183,1938

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 930 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 56,920,1967

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 530 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 182,348,1936

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 132,214,1928

TYPE OF TEST

其他信息

  • 三溴乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1420 2,2,2-三溴乙醇 2,2,2-Tribromoethanol 25G 999元 2014/06/02 T1420 2,2,2-三溴乙醇 2,2,2-Tribromoethanol 500G 8730元 2010/06/21 421430500 三溴乙醇 2,2,2-Tribromoethanol 99% 50 GR 1430元
  • Sigma Aldrich:75-80-9(sigmaaldrich)
  • 海关编码:29159080
  • Alfa Aesar:2,2,2-三溴乙醇,99% 2,2,2-Tribromoethanol, 99%(75-80-9)
  • 图谱信息:三溴乙醇(75-80-9)质谱(MS)
  • 类别:有毒物品
  • 毒性分级:中毒
  • 三溴乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 T1420 2,2,2-三溴乙醇 2,2,2-Tribromoethanol 25G 905元 2011/04/16 T1420 2,2,2-三溴乙醇 2,2,2-Tribromoethanol 500G 7910元 2010/06/21 421430500 三溴乙醇 2,2,2-Tribromoethanol 99% 50 GR 1430元
  • 可燃性危险特性:受热燃烧; 燃烧产生有毒溴化物烟雾
  • TCI Shanghai:2,2,2-三溴乙醇 2,2,2-Tribromoethanol,>;98.0%(GC)(75-80-9)
  • 储运特性:通风低温干燥
  • Acros Organics:三溴乙醇 2,2,2-Tribromoethanol, 99%(75-80-9)
  • MOL 文件:75-80-9.mol
  • MSDS 信息:2,2,2-Tribromoethanol(75-80-9).msds
  • 敏感性:Light Sensitive
  • 急性毒性:口服-大鼠 LDL0: 1000 毫克/公斤; 口服-小鼠 LD50: 930 毫克/公斤
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • F:8-23

系列性分类