CAS 75-21-8 MFCD00014482-Epoxyethane 环氧乙烷 TAO{mole}

Epoxyethane 环氧乙烷

CAS 75-21-8 MFCD00014482

化学结构图

SMILES: C1CO1

化学属性

Mol. Formula	C2H4O
Mol. Weight	44
Refractive index	n20/D 1.3597(lit.)
Boiling Point	10.7 °C(lit.)
Density	0.882 g/mL at 25 °C(lit.)
Melting Point	-111 °C (lit.)
Flash Point	<-17.7℃
Solubility	易溶于水、多数有机溶剂。

别名和识别编码

Chemical Name	Epoxyethane
MDL Number	MFCD00014482
CAS Number	75-21-8
Synonym	epapesticidechemicalcode042301 {uni_hamburg} Oxirane 环氧乙烷 Äthylenoxyd Mirror Ox 氧丙环 C2H4O Etylenu tlenek Epoxyethane Äthylenoxid Ethylenoxid OXIRANE Oxane 环氧乙烷,醇溶液環氧乙烷 Ciba-Geigy 9138 ETO Ethene oxide Anprolene Oxiran Ethyleneoxy 氧【口+元】 1,2-Epoxyaethan Amprolene Ethyleenoxide C₂H₄O (oxirane) Anproline ai3-26263 Oxidoethane Dimethylene oxide 1,2 Sterilizing gas ethylene oxide 100% 曙光红(四溴荧光素) NCI-C50088
PubChem Substance ID	6354
EC Number	200-849-9
Beilstein Registry Number	102378
Chemical Name Translation	环氧乙烷
Merck Number	3802
Wiswesser Line Notation	T3OTJ
LabNetwork Molecule ID	LN00225610
InChI	InChI=1S/C2H4O/c1-2-3-1/h1-2H2

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产品应用

⑴. 环氧乙烷（EO）为一种最简单的环醚，属于杂环类化合物，是重要的石化产品。环氧乙烷在低温下为无色透明液体，在常温下为无色带有醚刺激性气味的气体，气体的蒸气压高，30℃时可达141kPa，这种高蒸汽压决定了环氧乙烷熏蒸消毒时穿透力较强。
⑵. 环氧乙烷液体本身是一种良好的有机溶剂。环氧乙烷易爆炸，当空气中含有3%~80%环氧乙烷时，则形成爆炸性混合气体，遇明火时发生燃烧或爆炸。若将环氧乙烷液体和水以1：22以上比例相混合，则不再有易燃（爆）性。环氧乙烷与镁、银及其化合物相接触时可形成乙炔，也可发生爆炸
环氧乙烷是用途广泛的合成中间体。主要用于生产乙二醇，还可生产乙醇胺类、醚类、非离子表面活性剂、防冻剂、增塑剂、添加剂、香料、高能燃料、推进剂等。

安全信息

GHS Symbol

WGK Germany3

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P410+P403
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P201 Obtain special instructions before use. 使用前获取专门指示。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P308+P313
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P370+P378
P403+P235

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H331 Toxic if inhaled 吸入中毒
H280 Contains gas under pressure; may explode if heated 内含高压气体，遇热可能爆炸。
H335 May cause respiratory irritation 可能导致呼吸道刺激
H350 May cause cancer 可能致癌
H340 May cause genetic defects 可能导致遗传性缺陷
H319 Causes serious eye irritation 严重刺激眼睛
H220 Extremely flammable gas 极易燃气体。
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H302+H332

Hazard Codes F+,T F,T F+,T,F T

Personal Protective Equipment Eyeshields, Gloves

Signal word Danger

RTECSKX2450000

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R11 Highly flammable 非常易燃
R20 Harmful by inhalation 吸入有害
R46 May cause inheritable genetic damage 可能引起遗传基因损害
R45 May cause cancer 可能致癌
R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
R19 May form explosive peroxides 可能生成易爆的过氧化物质
R12 Extremely flammable 极端易燃
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R23 Toxic by inhalation 吸入有毒
R6 Explosive with or without contact with air 接触空气或者未接触空气会爆炸

Storage condition 储存温度 2-8℃ Refrigerator 密封2-8°C保存

Hazard Class2.3

UN Number UN 2037 2.3

Warnings 危化品目录(2015)

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1090 mg/kg/91W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   39,588,1979

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2576 mg/kg/95W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Tumorigenic - tumors at site of application
REFERENCE :
   ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde,
   Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene,
   Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed.
   Rep. Ger.)  V.155-169, 1971-1979.  For publisher information, see ZAOMDC. 
   Volume(issue)/page/year: 174,383,1981

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 33 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Brain and Coverings - tumors
   Blood - leukemia
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   75,105,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 292 mg/kg/95W-I
TOXIC EFFECTS :
   Tumorigenic

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - muscle weakness
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JOHYAY Journal of Hygiene.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.1-    1901-  Volume(issue)/page/year: 32,409,1932

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 836 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB214-270

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 72 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SPEADM Special Publication of the Entomological Society of America.  (4603
   Calvert Rd., College Park, MD 20740)  Volume(issue)/page/year: 78-1,17,1978

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 960 ppm/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Gastrointestinal - nausea or vomiting
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For

TYPE OF TEST            : TCLo - Lowest published toxi

{h

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 625 ppm/2H (Continuous)
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8,67,1986

TYPE OF TEST            : Muta

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 40 umol/plate
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 18,115,1980

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Human
DOSE/DURATION           : 60 ppm/12W (Intermittent)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 281,31,1992

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 287,283,1993

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 4 pph
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   6,15,1986

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 400 ppm/6H (Continuous)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springe

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 50 ppm/7H
SEX/DURATION            : male 2 year(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 3,60,1983

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 ppm/6H
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   48,A84,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 450 mg/kg
SEX/DURATION            : female 8-10 day(s) after conceptio

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 50 ppm/7H
SEX/DURATION            : male 96 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   ATAREK AAMI Technology Assessment Report.  (Assoc. for the Advancement of
   Medical Instrumentation, 1901 N. Ft. Myer Dr., Suite 602, Arlington, VA
   22209)  No.1-81-    1981-  Volume(issue)/page/year: 8-84,7,1984

Restrict 危险品

其他信息

⑴. 储存于阴凉、通风的专用库房。远离火种、热源。避免光照。库温不宜超过30℃。应与酸类、碱类、醇类、食用化学品分开存放，切忌混储。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备。 ⑵. 设备应密封，防止跑、冒、滴、漏。加强通风设施。操作人员应穿戴防护用具。高浓度环境中更应戴活性炭口罩或压缩空气、压缩厌氧呼吸面具。装置附近应备有水龙头及淋浴设备。空气中最高容许浓度0.001g/m3。 ⑶.操作时密闭操作，局部排风。操作人员必须经过专门培训，严格遵守操作规程。建议