Dideoxycytidine 4-氨基-1-((2R,5S)-5-(羟甲基)四氢呋喃-2-基)嘧啶-2(1H)-酮
CAS 7481-89-2 MFCD00012188
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {Chemicalbo
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, D-DIF, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides, 细胞生物学
- Nucleotides
- {SNA} AIDS and Viral Research Reagents, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuros
产品应用
- A pyrimidine nucleoside analogue with antiviral activity.
相关文献及参考
- van der Vliet, P.C. and Kwant, M.M.: Biochemistry, 20, 2628 (1981),
- Mitsuya, H., Broder, S.: Proc. Nat. Acad. Sci. USA, 83, 1911 (1986),
- Starnes, M.C., and Cheng, Y.: J. Biol. Chem., 262, 988 (1987),
安全信息
GHS Symbol
- S22 Do not breathe dust 不要吸入粉尘;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R62 Possible risk of impaired fertility 有削弱生殖能力的危险
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P305+P351+P338
- P308+P313
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H351 Suspected of causing cancer 怀疑致癌
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 91 mg/kg/13W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Endocrine - tumors REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,263,1995
TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 200 nmol/L REFERENCE : MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965- Volume(issue)/page/year: 39,625,1991
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 600 mg/kg/3D (Continuous) REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 18,168,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 20 gm/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 42,131,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 10 gm/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 42,131,1990
其他信息
- TCI Shanghai:2',3'-二脱氧胞苷 2',3'-Dideoxycytidine,>;98.0%(LC)(T)(7481-89-2)
- 用途二:作用于HIV复制的早期,抑制病毒的逆录酶和终止病毒DNA链的复制。用于晚期免疫缺陷病毒感染患者的治疗。
- Alfa Aesar:2',3'-二脱氧胞啶,98+% 2',3'-Dideoxycytidine, 98+%(7481-89-2)
- 上游原料:氨 --> 钯 --> 氢 --> 乙酰溴 --> 胞苷
- 图谱信息:扎西他滨(7481-89-2)红外图谱(IR1) 扎西他滨(7481-89-2)质谱(MS)
- 用途一:抗病毒药,用于抗癌、抗艾滋病毒
- F:10-23
- 方法一:N-乙酰基胞嘧啶核苷(4g,14mmo1)在200ml乙腈中回流,在30min内滴加乙酰溴(10ml,0.137mo1),加毕再回流3h。蒸出溶剂,剩余物溶于100ml氯仿后,用100ml水洗。蒸去氯仿,剩余物用10ml乙醇重结晶,得2g无色片状结晶的化合物(I),收率33%,熔点179-180℃(分解)。 化合物(I)(1g,2.3mmo1)、lg碳酸钙、0.2g钯-硫酸钡和50ml 50%甲醇,在25℃和常压下与氢气摇晃1h(吸收60ml氢)。过滤除去结晶,滤液浓缩至干。剩余物溶于10ml 20%氨-甲醇溶液,于5℃下放置过夜。柱层析后再用乙醇重结晶,得34mg无色结晶的扎西他滨,收率7%。
- 扎西他滨价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D3581 2',3'-二脱氧胞苷 2',3'-Dideoxycytidine 1G 1390元 2010/05/25 L10619 2',3'-二脱氧胞啶, 98+% 2',3'-Dideoxycytidine, 98+% 50mg 749元 2010/05/25 L10619 2',3'-二脱氧胞啶, 98+% 2',3'-Dideoxycytidine, 98+% 250mg 2674元
- MSDS 信息:DDC(7481-89-2).msds
- Sigma Aldrich:7481-89-2(sigmaaldrich)
- MOL 文件:7481-89-2.mol