2-amino-2-(hydroxymethyl)propane-1,3-diol 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate 2-氨基-2-(羟甲基)丙烷-1,3-二醇5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-羧酸酯
CAS 74103-07-4 MFCD00887595
化学结构图
SMILES: NC(CO)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1C=CC=CC=1
化学属性
| Mol. Formula | C15H13NO3·C4H11NO3 |
|---|---|
| Mol. Weight | 376.41 |
| Melting Point | 165.0 to 169.0 deg-C |
别名和识别编码
| Chemical Name | 2-amino-2-(hydroxymethyl)propane-1,3-diol 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate |
|---|---|
| CAS Number | 74103-07-4 |
| Synonym | (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt Toradol Dolac Ketanov Ketorol Ketorolac Tris Salt Ketorolac tris salt Ketorolac trometamol Ketorolac tromethamine Lixidol Syntex Tarazyn Toradol Toratex Trometamol Ketorolac |
| MDL Number | MFCD00887595 |
| PubChem Substance ID | 253661330 |
| Chemical Name Translation | 2-氨基-2-(羟甲基)丙烷-1,3-二醇5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-羧酸酯 |
| Reaxys-RN | 6463165 |
| Merck Number | 5306 |
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资金保障
专业采购外包团队在线服务
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分类
- {SNA} A to C, Application Index, Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents,
- {SNA} A to C, Application Index, Arachidonic Acid Cascade, Cell Signaling Enzymes, Cyclooxygenase, Cyclooxygenase (COX) Enzymes, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Lipids in Cell Signaling, P to Q, Prostaglandin H synthetases 1 (COX-1) and 2 (COX-2), 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- Inhibitors
- Heterocycles
- Pharmaceuticals
- {SA} A to C, Application Index, Arachidonic Acid Cascade, Bioactive Small Molecules,
- Intermediates & Fine Che
产品应用
- Ketorolac is an analgesic; anti-inflammatory.
相关文献及参考
- Etman, M., et al.: Pharm. Technol., 32, 58 (2008),
- Chelladurai, S., et al.: Chem. Pharm. Bull., 56, 1596 (2008),
- Cirino, G., et al., Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory derivatives with gastrointestinal-sparing properties. Br. J. Pharmacol. 117 , 1421, (1996) 摘要
- Tripathi, A., Welch, S.P., Blockade of the antinociceptive activity of centrally administered ketorolac by nor-binaltorphimine. Eur. J. Pharmacol. 278 , 27, (1995) 摘要
- Laneuville, O., Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 271 , 927, (1994) 摘要
- Michel, R.E., et al., Ketorolac causes the release of methionine-enkephalin in rats. Res. Commun. Mol. Pathol. Pharmacol. 91 , 249, (1996) 摘要
- Scarlett, J.M., et al., Regulation of Central Melanocortin Signaling by Interleukin-1{beta} Endocrinology 148 , 4217-25, (2007) 摘要
- Scarlett, J.M., et al., Regulation of Agouti-Related Protein Messenger Ribonucleic Acid Transcription and Peptide Secretion by Acute and Chronic Inflammation Endocrinology 149 , 4837-45, (2008) 摘要
- Zhang, Y., et al., Crystal Structure Of The Receptor Binding Domain Of The Botulinum C-D Mosaic Neurotoxin Reveals Potential Roles Of Lysines 1118 And 1136 In Membrane Interactions. Biochem. Biophys. Res. Commun. 404 , 407-12, (2011) 摘要
- Merck 14 ,5306
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310
- P301+P310+P330
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H301 Toxic if swallowed 吞食有毒
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - man DOSE/DURATION : 858 ug/kg TOXIC EFFECTS : Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - dyspnea Immunological Including Allergic - anaphylaxis REFERENCE : APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 26,1237,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - woman DOSE/DURATION : 1200 ug/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - bronchiolar constriction Lungs, Thorax, or Respiration - dyspnea REFERENCE : SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 87,282,1994
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - man DOSE/DURATION : 19853 ug/kg/12D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubul
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - man DOSE/DURATION : 857 ug/kg TOXIC EFFECTS : Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 32,305,1994
