• 原料直供
• 试剂商城
• 直接询价

分类

• {Chemicalbook} 农药中间体: 杀菌剂中间体: 三唑类杀菌剂
• {SNA} Alphabetical Index of Analytical Standards, Chemical Class, Alpha Sort, Analytical Standards, Analytical/Chromatography, Bromo, Chromatography, D, DIA - DIC, Environmental Standards, Halogenated, Volatiles/ Semivolatiles
• {

产品应用

• 有机合成。溶剂。

相关文献及参考

• With alcohols, formaldehyde acetals can be formed under phase-transfer conditions: Bull. Chem. Soc. Jpn., 66, 2149 (1993). Diols give methylenedioxy derivatives, which are components of many biologically-important molecules. For use of KF in DMF as base in the methylenation of catechols, see: Tetrahedron Lett., 3361 (1976). KOH in DMSO has been recommended for the methylenation of base-stable carbohydrate diols: Synthesis, 421 (1982). For the methylenation of ribonucleosides under phase-transfer conditions, see: Synthesis, 715 (1981).
• Short: II/19b
• The Simmons-Smith reaction (see Diiodomethane, A15457) may be extended to the use of dibromomethane in the cyclopropanation of simple electron-deficient alkenes, using a reducing agent prepared from NiBr2, NaI and Zn: Bull. Chem. Soc. Jpn., 56, 1025 (1983); or with CuCl/Zn: J. Org. Chem., 55, 2491 (1990).
• Merck: 14,6061
• Reaction with NaHMDS generates monobromocarbene, which reacts with alkenes to give bromocyclopropanes: Synthesis, 201 (1972). It can also be generated by reaction with diethylzinc in the presence of O2: J. Chem. Soc., Chem. Commun., 364 (1975).
• Merck: 14,6061 Beilstein: 1,IV,78
• For in situ formation of dibromomethyllithium by reaction with lithiated 2,2,6,6-Tetramethyl­piperidine, A18712, and use in a one-pot ester homologation sequence, safer and more convenient than the classical Arndt-Eistert (diazomethane) method, see: Org. Synth. Coll., 9, 426 (1998):
• With TiCl4/Zn, methylenation of ketones occurs, as a useful mild alternative to the Wittig reaction: Tetrahedron Lett., 23, 4293 (1982); Org. Synth. Coll., 8, 386 (1993). For a variant using Zn, CuCl and catalytic TiCl4, see: J. Org. Chem., 54, 2388 (1989).
• Short: II/24B

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DOWCC* Dow Chemical Company Reports.  (Dow Chemical USA, Health and
   Environment Research, Toxicology Research Lab., Midland, MI 48640)
   Volume(issue)/page/year: MSD-472

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3738 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   4,354,1962

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 gm/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,83,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DOWCC* Dow Chemical Company Reports.  (Dow Chemical USA, Health and
   Environment Research, Toxicology Research Lab., Midland, MI 48640)
   Volume(issue)/page/year: MSD-472

TYPE OF TEST            : LD50 - Lethal dose, 50 perc

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   TECSDY Toxicological and Environmental Chemistry.  (Gordon & Breach Science
   Pub. Inc., 1 Park Ave., New York, NY 10016)  V.3(3/4)-    1981-
   Volume(issue)/page/year: 13,205,1987

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 umol/L
REFERENCE :
   TECSDY Toxicological and Environmental Chemistry.  (Gordon & Breach Science
   Pub. Inc., 1 Park Ave., New York, NY 10016)  V.3(3/4)-    1981-
   Volume(issue)/page/year: 13,205,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ng/plate
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 24,590,1980

其他信息

• 用途四:有机合成原料。可作溶剂、致冷剂、阻燃剂和抗爆剂的组分；在医药工业上用作消毒剂和镇痛剂。还用于农药腈菌唑和其他有机合成等。
• Acros Organics:二溴甲烷 Dibromomethane, 99+%(74-95-3)
• MOL 文件:74-95-3.mol
• 职业标准:TWA 10 毫克/立方米; STEL 10 毫克/立方米
• Sigma Aldrich:74-95-3(sigmaaldrich)
• 上游原料:二氯甲烷 --> 三溴甲烷 --> 溴氯甲烷
• 类别:有毒物品
• Alfa Aesar:二溴甲烷,99%,50ppmBHT作稳定剂 Dibromomethane, 99%, stab. with 50ppm BHT(74-95-3)
• 用途三:二溴甲烷是制备杀菌剂腈菌唑和咪菌唑的原料。
• 蒸气密度:6.05 (vs air)
• 急性毒性:口服-大鼠LD50: 108 毫克/公斤; 皮下-小
• 方法二:1.三溴甲烷法　先用三氧化二砷和液碱反应，配制亚砷酸钠液，将亚砷酸钠液加热至65℃，在搅拌下徐徐加入溴仿，全部加完后继续搅拌回流4h，使反应完全，将反应物倾入5-6倍水中，吸出油状物，进行分馏。再用水洗至中性，用氯化钙脱水、精馏，得产品。原料消耗定额：溴仿8300kg/t、三氧化二砷1200kg/t、40%液碱16500kg/t。2.二氯甲烷法　在工业上尚有将无水CH2Cl2在无水AlBr3催化下与HBr反应制取，同时还产生氯溴甲烷。3.溴氯甲烷溴化氢法。
• 用途一:用作溶剂，也用于有机合成
• 蒸气压:34.9 mm Hg ( 20 °C)
• 二溴甲烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80043726 二溴甲烷;溴化亚甲基; 亚甲基二溴 100ml 187.2元 2011/04/16 S0636 二溴甲烷(1mg/ml的甲醇溶液)[用于水分析] Dibromomethane (1mg/ml in Methanol) [for Water Analysis] 1ML 198元 2011/04/16 D0192 二溴甲烷 Dibromomethane 25G 124元
• TCI Shanghai:二溴甲烷(1mg/ml的甲醇溶液)[用于水分析] Dibromomethane (1mg/ml in Methanol) [for Water Analysis](74-95-3)
• 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂分开存放
• 可燃性危险特性:高热分解产生溴化物气体
• 图谱信息:二溴甲烷(74-95-3)核磁图( 1 HNMR) 二溴甲烷(74-95-3)红外图谱(IR1) 二溴甲烷(74-95-3)核磁图( 13 CNMR) 二溴甲烷(74-95-3)质谱(MS)
• 毒性分级:高毒
• 灭火剂:干粉、泡沫、二氧化碳、砂土。
• 下游产品:1R,3R-二溴菊酸 --> 3-异丙基-二甲基苄基异氰酸酯TMI --> 乙烯基环己烷 --> 十溴二苯醚 --> 腈菌唑 --> 纳斯特试剂 --> 丁硫环磷 --> 1,3-苯并二氧-4-甲醛 --> 1,3-苯并二氧-5-磺酰氯 --> 1-溴-2-氰基-2-(4-氯苯基)己烷
• 用途二:用作有机合成原料，可作溶剂、制冷剂、阻燃剂和抗爆剂组分
• 外观性质:无色液体。
• MSDS 信息:二溴甲烷(74-95-3).msds
• 方法一:其制备方法是由二氯甲烷与溴反应或溴氯甲烷与溴化氢反应而制得。反应方程式：CH 2 Cl 2 +Br 2 →CH 2 Br 2 +Cl 2 CH 2 BrCl+HBr→CH 2 Br 2 +HCl
• 能与乙醇、乙醚、氯仿、丙酮混溶，水中溶解度: 1 g/L (20°C)。有毒，致死浓度(大鼠，吸入)60mg/L。