3-((Quinolin-4-Ylmethyl)Amino)-N-(4-(Trifluoromethoxy)Phenyl)Thiophene-2-Carboxamide 3-((喹啉-4-基甲基)氨基)-N-(4-(三氟甲氧基)苯基)噻吩-2-甲酰胺
CAS 728033-96-3 MFCD28033963
化学结构图
SMILES: O=C(Nc1ccc(OC(F)(F)F)cc1)c1sccc1NCc1ccnc2ccccc12
化学属性
| Mol. Weight | 443.44 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 3-((Quinolin-4-Ylmethyl)Amino)-N-(4-(Trifluoromethoxy)Phenyl)Thiophene-2-Carboxamide |
|---|---|
| Formula | C22H16F3N3O2S |
| Synonym | OSI-930; OSI 930; OSI930. |
| IUPAC Name | 3-((quinolin-4-ylmethyl)amino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide |
| InChIKey | FGTCROZDHDSNIO-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H16F3N3O2S/c23-22(24,25)30-16-7-5-15(6-8-16)28-21(29)20-19(10-12-31-20)27-13-14-9-11-26-18-4-2-1-3-17(14)18/h1-12,27H,13H2,(H,28,29) |
| Canonical SMILES | O=C(C1=C(NCC2=CC=NC3=CC=CC=C23)C=CS1)NC4=CC=C(OC(F)(F)F)C=C4 |
| Chemical Name Translation | 3-((喹啉-4-基甲基)氨基)-N-(4-(三氟甲氧基)苯基)噻吩-2-甲酰胺 |
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产品应用
- OSI-930 is a selective thiophene-derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI-930 inhibits stem cell factor receptor (c-Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c-Kit and VEGFR2 are overexpressed in a variety of cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
