1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione,8,16-bis(5-oxazolylmethyl)-3,5,7,11,13,15-hexamethyl-,(5R-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))-
CAS 72263-05-9 MFCD01730317
化学结构图
SMILES: CC1=C[C@H](C)C[C@H](C)[C@H](CC2=CN=CO2)OC(=O)C(C)=C[C@H](C)C[C@H](C)[C@H](CC2=CN=CO2)OC1=O |c:1,12,31,t:10,20,29|
化学属性
| Mol. Formula | C28H38N2O6 |
|---|---|
| Mol. Weight | 498.68 |
别名和识别编码
| Chemical Name | 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione,8,16-bis(5-oxazolylmethyl)-3,5,7,11,13,15-hexamethyl-,(5R-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- |
|---|---|
| Synonym | Conglobatin (-)-Conglobatin |
| Beilstein Registry Number | 5321648 |
| CAS Number | 72263-05-9 |
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相关文献及参考
- [2]. Huang W, et, al. FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol Cancer. 2014 Jun 14;13:150.
- [3]. Li LY, et, al. Macrolide analog F806 suppresses esophageal squamous cell carcinoma (ESCC) by blocking β1 integrin activation. Oncotarget. 2015 Jun 30;6(18):15940-52.
- [1]. Westley JW, et, al. Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005. J Antibiot (Tokyo). 1979 Sep;32(9):874-7.
- [1]. Westley JW, et, al. Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005. J Antibiot (Tokyo). 1979 Sep;32(9):874-7.
- [2]. Huang W, et, al. FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol Cancer. 2014 Jun 14;13:150.
- [3]. Li LY, et, al. Macrolide analog F806
安全信息
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 32,874,1979
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 32,874,1979
