3-[[7-[3-[Ethyl(2-Hydroxyethyl)Amino]Propoxy]-4-Quinazoline]Amino]-N-(3-Fluorophenyl)-1H-Pyrazole-3-Acetamide 5-[[7-[3-[乙基(2-羟基乙基)氨基]丙氧基]-4-喹唑啉]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺
CAS 722544-51-6 MFCD10687152
化学结构图
SMILES: CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1
化学属性
| Mol. Formula | C26H30FN7O3 |
|---|---|
| Mol. Weight | 507.56 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 3-[[7-[3-[Ethyl(2-Hydroxyethyl)Amino]Propoxy]-4-Quinazoline]Amino]-N-(3-Fluorophenyl)-1H-Pyrazole-3-Acetamide |
|---|---|
| Synonym | 3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide AZD-2811; AZD 2811; AZD2811; AZD-1152HQPA; AZD 1152HQPA; AZD1152HQPA; AZD1152 HQPA; AZD1152-HQPA; AZD1152HQPA. AZD1152-HQPA |
| CAS Number | 722544-51-6 |
| MDL Number | MFCD10687152 |
| PubChem Substance ID | 16007391 |
| InChI | InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) |
| LabNetwork Molecule ID | LN01274609 |
| Chemical Name Translation | 5-[[7-[3-[乙基(2-羟基乙基)氨基]丙氧基]-4-喹唑啉]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺 |
| Formula | C26H30FN7O3 |
| IUPAC Name | 2-(3-((7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-yl)amino)-1H-pyrazol-5-yl)-N-(3-fluorophenyl)acetamide |
| InChIKey | QYZOGCMHVIGURT-UHFFFAOYSA-N |
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分类
- {SNA} AN-AZ, Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, New Products, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
产品应用
- AZD-1152 HQPA, also known as AZD-2811, is a potent and selective Aurora B inhibitor (IC50 of 0.37 nM versus 1368 nM for Aurora B and A kinases, respectively) and is also an active metabolite of Barasertib ( AZD-1152). Barasertib is a prodrug and will be converted rapidly to the active drug AZD1152-HQPA in human plasma. Preliminary studies showed that AZD-1152 was active against a variety of solid tumors including colon, breast, and lung cancers. IMPORTANT NOTE: AZD-1152HQPA IS NOT AZD-1152 or Barasertib. Many vendors is selling Barasertib with wrong structure
相关文献及参考
- Mori, N., et al., Effects of AZD1152, a selective Aurora B kinase inhibitor, on Burkitt's and Hodgkin's lymphomas. Biochem. Pharmacol. 81 , 1106-1115, (2011)
- Lordier, L., et al., Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process. Blood 116 , 2345-2355, (2010)
- Grundy, M., et al., The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells. Mol. Cancer Ther. 9 , 661-672, (2010)
