VAS 2870 2-((3-苄基-3H- [1,2,3]三唑并[4,5-d]嘧啶-7-基)硫基)苯并[d]恶唑
CAS 722456-31-7 MFCD03407188
化学结构图
SMILES: C(C1C=CC=CC=1)N1N=NC2C(=NC=NC1=2)SC1=NC2C=CC=CC=2O1
化学属性
| Mol. Formula | C18H12N6OS |
|---|---|
| Mol. Weight | 360.39 |
别名和识别编码
| Chemical Name | VAS 2870 |
|---|---|
| Synonym | 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine VAS 2870 VAS-2870 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine VAS 2870 VAS-2870 VAS2870 |
| MDL Number | MFCD03407188 |
| Chemical Name Translation | 2-((3-苄基-3H- [1,2,3]三唑并[4,5-d]嘧啶-7-基)硫基)苯并[d]恶唑 |
| PubChem Substance ID | 329825281 |
| CAS Number | 722456-31-7 |
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分类
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Nitric Oxide Metabolism, Nitric Oxide Synthase Regulators, Nitric Oxide and Cell Stress
- {SNA} Bioactive Small Molecule Alphabetical Index, Nitric Oxide Synthase Regulators, V, 一氧化氮代谢, 一氧化氮和细胞应激, 生物活性小分子, 细胞信号转导和神经科学,
相关文献及参考
- [2]. Sancho P, et al. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem Pharmacol. 2011 Apr 1;81(7):917-24.
- [1]. ten Freyhaus H, et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res. 2006 Jul 15;71(2):331-41.
- [1]. ten Freyhaus H, et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res. 2006 Jul 15;71(2):331-41.
- [2]. Sancho P, et al. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem Pharmacol. 2011 Apr 1;81(7):917-24.
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
