CAS 71675-85-9 MFCD00866691-Amisulpride 阿米舒必利 TAO{mole}

Amisulpride 阿米舒必利

CAS 71675-85-9 MFCD00866691

化学结构图

SMILES: COC1C=C(N)C(=CC=1C(=O)NCC1CCCN1CC)S(=O)(=O)CC

化学属性

Mol. Formula	C17H27N3O4S
Mol. Weight	369
Appearance	solid 白色至类白色结晶性粉末。
Solubility	DMSO: >=5 mg/mL
Melting Point	125-129

别名和识别编码

Chemical Name	Amisulpride
CAS Number	71675-85-9
Synonym	36005 a 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-ethylsulfonyl-2-methoxybenzamide 4-amino-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzam ALIZAPRIDE AMISULPRIDE DAN 2163 DAN-2163 DENIBAN Solian Sulamid benzamide,4-amino-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-metho
MDL Number	MFCD00866691
PubChem Substance ID	135727298
EC Number	275-831-7
Chemical Name Translation	阿米舒必利
Reaxys-RN	6876191
Merck Number	485
Beilstein Registry Number	6876191

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分类

Aromatics
Drug Analogues
Heterocycles
Pharmaceuticals
Intermediates & Fine Chemicals
Sulfur & Selenium Compounds
{SNA} A-AM, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, Sanofi Aventis

产品应用

Amisulpride is a neuroleptic agent, an analogue of Sulpiride (S689145). Amisulpride is used as an antipsychotic. Amisulpride is a dopamine receptor antagonist.

安全信息

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

WGK Germany3

Signal word Warning

RTECSCV2308701

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S22 Do not breathe dust 不要吸入粉尘；

Hazard Codes Xn

Risk Statements

R22 Harmful if swallowed 吞咽有害

Storage condition 0-10 2-8°C 0-10°C

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P312+P330
P501 Dispose of contents/container to..… 处理内容物/容器.....

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1024 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4401822

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4401822

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4401822

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 224 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4401822

其他信息

Sigma Aldrich:71675-85-9(sigmaaldrich)