CAS 71-58-9 MFCD00010483-Medroxyprogesterone 17-Acetate 醋酸甲羟孕酮 TAO{mole}

Medroxyprogesterone 17-Acetate 醋酸甲羟孕酮

CAS 71-58-9 MFCD00010483

化学结构图

SMILES: CC(=O)OCC1CC(=O)C=C2CC[C@@H]3[C@H](CC[C@]4(C)[C@@H](C(C)=O)CC[C@@H]34)[C@]21C

化学属性

Mol. Formula	C24H34O4
Mol. Weight	387
Melting Point	203-209
Appearance	白色或类白色结晶性粉末, 无臭。不溶于水，微溶于乙醇，溶于丙酮，极易溶于三氯甲烷。
Solubility	DMSO 12 mg/mL Water <1 mg/mL Ethanol 12 mg/mL
Refractive index	48 ° (C=1, Dioxane)

别名和识别编码

Chemical Name	Medroxyprogesterone 17-Acetate
Synonym	(6-alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione 17α-乙酰氧基-6α-甲基孕酮 17α-羟基-6α-甲基-4-孕烯-3,20-二酮 17-乙酸酯 6α-甲基-17α-乙酰氧孕酮 6α-甲基-17α-羟基孕酮乙酸酯 17-(acetyloxy)-6-methyl-(6-alpha)-pregn-4-ene-20-dione 17-(acetyloxy)-6-methyl-20-dion(6alpha)-pregn-4-ene- 17-Hydroxy-6-alpha-methylpregn-4-ene-3,20-dione acetate 17-alpha-Acetoxy-6-alpha-methylpregn-4-ene-3,20-dione 6α-甲基-17α-乙酰氧孕酮 6-alpha-Methyl-4-pregnene-3,20-dion-17-alpha-ol acetate 6ALPHA-METHYL DEPO-PROVERA DMPA Depo-Medroxyprogesterone ace Depo-Provera Farlutal Medroxyacetate pro Medroxyprogesterone 17-acetate Perlutex Repromap 甲羟孕酮醋酸酯
MDL Number	MFCD00010483
PubChem Substance ID	6279
Beilstein Registry Number	2066112
CAS Number	71-58-9
EC Number	200-757-9
Chemical Name Translation	醋酸甲羟孕酮
Merck Number	13,5817
Reaxys-RN	2066112
Wiswesser Line Notation	L E5 B666 OV MUTJ A1 E1 FV1 FOV1 L1
LabNetwork Molecule ID	LN00246440
InChI	InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1

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安全信息

RTECSTU5010000

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P308+P313
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H351 Suspected of causing cancer 怀疑致癌

Hazard Codes Xn

WGK Germany3

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Gloves

Signal word Warning

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险

Storage condition 储存温度-20°C

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1240 mg/kg/4Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 31,340,1979

TYPE OF TEST            : TD - Toxic dose (other than

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   59,210,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 30 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
   Skin and Appendages - tumors
REFERENCE :
   36PYAS "Pharmacology of Steroid Contraceptive Drugs," Garattini, S. and H.W.
   Berendes, eds., New York, Raven Press, 1977  Volume(issue)/page/year:
   -,145,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9600 mg/kg/1Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   33,215,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 18,6135,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - increased intraocular pressure
REFERENCE :
   ADVPB4 Advances in Planned Parenthood.  (Excerpta Medica, Inc., POB 3085,
   Princeton, NJ 08540) V.1-16, 1967-81.

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >16 gm/kg
TOXIC EFFECTS :
   Endocrine - adrenal cortex hypoplasia
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 18

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 18,6135,1

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 umol/L
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 146,401,1974

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 395,179,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 12 mg/kg
SEX/DURATION            : female 4 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   PHRPA6 Public Health Reports.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402)  V.1-    1878-  Volume(issue)/page/year:
   84,1059,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE                    : 4 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 21,525,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE                    : 3 mg/kg
SEX/DURATION            : female 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 17,261,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       :

其他信息

安宫黄体酮价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 M1964 醋酸甲羟孕酮 Medroxyprogesterone Acetate 5G 1020元 2014/06/02 M1964 醋酸甲羟孕酮 Medroxyprogesterone Acetate 1G 380元
MOL 文件:71-58-9.mol
Sigma Aldrich:71-58-9(sigmaaldrich)
TCI Shanghai:甲羟孕酮乙酸酯 Medroxyprogesterone Acetate,>;93.0%(GC)(71-58-9)
用途一:用于治疗晚期乳腺癌、子宫内膜腺癌及肾癌
醋酸甲羟孕酮
MSDS 信息:17a-Hydroxy-6a-methyl-4-pregnene-3,20-dione acetate(71-58-9).msds
图谱信息:安宫黄体酮(71-58-9)红外图谱(IR1) 安宫黄体酮(71-58-9)红外图谱(IR2) 安宫黄体酮(71-58-9)质谱(MS)