CAS 7083-71-8 MFCD00149309-Emetine dihydrochloride hydrate Emetine TAO{mole}

Emetine dihydrochloride hydrate Emetine

CAS 7083-71-8 MFCD00149309

化学结构图

SMILES: CCC1CN2CCc3cc(OC)c(OC)cc3C2CC1CC1NCCc2cc(OC)c(OC)cc21.Cl.Cl.O

化学属性

Mol. Formula	C29H40N2O4· 2HCl · xH2O
Mol. Weight	553.56 (anhydrous basis)
Melting Point	240-250 °C (dec., dry matter)(lit.)

别名和识别编码

Chemical Name	Emetine dihydrochloride hydrate
MDL Number	MFCD00149309
PubChem Substance ID	201899
Beilstein Registry Number	5216794
EC Number	206-259-8
Synonym	Amebicide Purum Emetine dihydrochloride hydrate l-Emetine dihydrochloride AI3-50600 (-)-Emetine dihydrochloride Emetan, 6',7',10,11-tetramethoxy-, dihydrochloride NSC-33669
Wiswesser Line Notation	T B666 GNTT&J E2 LO1 MO1 D1- BT66 CMT&J HO1 IO1 &GH&GH
CAS Number	316-42-7
InChI	InChI=1S/C29H40N2O4.2ClH.H2O/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H;1H2/t18-,21-,24+,25-;;;/m0.../s1
Chemical Name Translation	Emetine

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分类

{SNA} Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiparasitic / Antiprotozoal / Anthelminthic, Bioactive Small Molecule Alphabetical Index, Chemical Structure Class, E, Gene Regulation and Expression, Interferes with Protein Synthesis, Mechanism of Action, Miscellaneous, RNA-Protein Translation Inhibitors, Spectrum of Activity, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
{SNA} Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P301+P316
P302+P350
P302+P352
P304+P340
P305+P351+P338
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P316
P319
P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P337+P313
P337+P317
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P361+P364
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H300 Fatal if swallowed 吞食致命
H310 Fatal in contact with skin 皮肤接触致命
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H330 Fatal if inhaled 吸入致命
H335 May cause respiratory irritation 可能导致呼吸道刺激

Signal word Danger

Hazard Codes T+

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R28 Very toxic if swallowed 吞咽极毒

Warnings 危化品目录(2015)

RTECSJY5250000

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Cardiac - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AJTMAQ American Journal of Tropical Medicine.  (Baltimore, MD)  V.1-31,
   1921-51.  For publisher information, see AJTHAB.  Volume(issue)/page/year:
   10,249,1930

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 13886 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IMGAAY Indian Medical Gazette.  (Block F, 105-C, New Alipore, Calcutta 700
   053, India) V.1-90, 1866-1955; New series: V.1-    1961-
   Volume(issue)/page/year: 49,85,1914

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16200 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/ye

TYPE OF TEST            : LD50 - Lethal do

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V