Cefaclor Monohydrate 头孢克洛一水合物
CAS 70356-03-5 MFCD00071999
化学结构图
SMILES: O.N[C@H](C1C=CC=CC=1)C(=O)N[C@H]1[C@H]2SCC(Cl)=C(C(O)=O)N2C1=O
化学属性
| Mol. Formula | C15H14ClN3O4S.H2O |
|---|---|
| Mol. Weight | 385.85 |
别名和识别编码
| Chemical Name | Cefaclor Monohydrate |
|---|---|
| CAS Number | 70356-03-5 |
| Synonym | Lilly 99638 hydrate Panoral hydrate Raniclor Ceclor Keflor Distaclor (6R,7R)-7-[(2-Amino-2-phenylacetyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Monohydrate Cefaclor hydrate |
| Chemical Name Translation | 头孢克洛一水合物 |
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分类
- Chiral Reagents
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds,
产品应用
- Second-generation cephalosporin antibiotic. Antibacterial.
相关文献及参考
- Gray, B.M., et al.: Antimicrob. Agents Chemother., 13, 988 (1978),
- Lorenz, L.J., et al.: Anal. Profiles Drug Subs., 9, 107 (1980),
- Hori, R., et al.: J. Pharm. Pharmacol., 40, 646 (1988),
安全信息
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting REFERENCE : PMESAJ Postgraduate Medical Journal, Supplement. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1949- Volume(issue)/page/year: 55(Suppl 4),17,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1227 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4838 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >20 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982
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