CAS 70-30-4 MFCD00002171-Hexachlorophene 六氯酚 TAO{mole}

Hexachlorophene 六氯酚

CAS 70-30-4 MFCD00002171

化学结构图

SMILES: Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl

化学属性

Mol. Formula	CH2[C6H(Cl)3OH]2
Mol. Weight	406.90
Melting Point	163-165 °C(lit.)
Flash Point	11 °C
Appearance	crystalline
Solubility	不溶于水，溶于醇、丙酮、乙醚、氯仿、丙二醇、油类、稀碱液。
Density	1.713

别名和识别编码

Chemical Name	Hexachlorophene
CAS Number	70-30-4
Synonym	AT 7 2,2'-亚甲基双(3,4,6-三氯苯酚) bis(3,5,6-trichloro-2-hydroxy phenyl)methane Hexa HCP Bis(2-hydroxy-3,5,6-trichlorophenyl)methane SERIBAK Gamophene Compound G-11 2,2'-Methylenebis(3,4,6-trichlorophenol) DIHYDROXYHEXACHLORODIPHENYLMETHANE Hexabalm Acigena 3,3',4,4',6,6'-hexachloro-2,2'-methylenediphenol 2,2'-methylenebis(3,4,6-trichlorophenol) 2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane 毒菌酚 ######## NCI-C02653 B 32 {uni_hambur 六氯芬 2,2'-DIHYDROXY-3,5,6,3',5',6'-HEXACHLORODIPHENYL METHANE 2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane Hexafen Hexachlorofen Septofen 2,2'-dihydroxy-3,3',5,5',6,6'-hexachlo Ritosept Hexo AT-17 Fesia-sin Phenol, 2,2' 2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane Exofene Hexosan {uni 3,3',5,5',6,6'-HEXACHLORO-2,2'-DIHYDROXYDIPHENYLMETHANE BIS-(3,4,6-T AT-7 Methane, bis(2,3,5-trichloro-6-hydroxyphenyl) Septisol 2,2'-Methylenebis[3,4,6-trichlorophenol] Fostril 2,2′-亚甲基双(3,4,6-三氯苯酚) hexachlorophene G 11 甲双三氯酚雙(3,5,6-三氯-2-羥苯)甲烷 Fomac Gamophen G 11 (bactericide) S 2,2'-Methylen-bis-(3,4,6-trichlorphenol) hexachlorophene (INN) Steraskin Germa-Medica {Che
Beilstein Registry Number	2064407
EC Number	200-733-8
MDL Number	MFCD00002171
PubChem Substance ID	3598
Chemical Name Translation	六氯酚
Merck Number	4680
Wiswesser Line Notation	QR BG DG EG F1R BQ CG EG FG
InChI	InChI=1S/C13H6Cl6O2/c14-6-2-8(16)12(20)4(10(6)18)1-5-11(19)7(15)3-9(17)13(5)21/h2-3,20-21H,1H2

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

六氯酚对革兰氏阳性菌特别有效，而对革半氏阴性菌效力差，对高酸菌、霉菌及牙胞杆菌、病毒、螺旋体等无效。石炭酸系数为125。该品曾大量用于痱子、襁褓斑疹、面疱的治疗药及婴儿扑粉、药皂等。对氯酚对皮肤几乎没有刺激作用。

安全信息

Precautionary statements

P301+P310
P501 Dispose of contents/container to..… 处理内容物/容器.....
P273 Avoid release to the environment. 避免释放到环境中。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

GHS Symbol

WGK Germany3

Signal word Danger

Hazard statements

H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒
H301+H311

Hazard Codes T,N,F T,N T;N

RTECSSM0700000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Safety Statements

S37 Wear suitable gloves 戴适当手套；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S20 When using do not eat or drink 使用时，不得进食，饮水；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
R11 Highly flammable 非常易燃
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R52/53
R50/53

UN Number 2875 UN 2875 6.1/PG 3

Packing GroupIII

Hazard Class6.1(b)

Storage condition 2-8°C

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 33500 ug/m3/52W
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 33(1),62,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8400 mg/kg/21W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   19,413,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 257 mg/kg/7D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Gastrointestinal - hypermotility, diarrhea
   Vascular - shock
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(10),26,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 8500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JSCCA5 Journal of the Society of Cosmetic Chemists.  (Soc. of Cosmetic
   Chemists, 1995 Broadway, Suite 1701, New York, NY 10023)  V.1-    1947-
   Volume(issue)/page/year: 20,173,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent k

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 8-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   28,43,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : female 8-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   28,43,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 435 mg/kg
SEX/DURATION            : female 15-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   FCTXAV Food and Cosmetics

其他信息

MSDS 信息:双(3,5,6-三氯-2-羟基苯)甲烷(70-30-4).msds
灭火剂:砂土、干粉、泡沫
外观性质:白色或浅褐色粉末。
上游原料:发烟硫酸 --> 连二亚硫酸钠 --> 多聚甲醛 --> 二氯乙烷 --> 2,4,5-三氯苯酚 --> 脱色炭
类别:农药
毒性分级:高毒
MOL 文件:70-30-4.mol
color:off-white to tan
刺激数据:皮肤-兔子 0.03 毫克轻度; 眼睛-兔子 1500 毫克/24小时中度
储运特性:库房通风低温干燥; 与食品原料分开储运
用途一:六氯酚对革兰氏阳性菌特别有效，而对革半氏阴性菌效力差，对高酸菌、霉菌及牙胞杆菌、病毒、螺旋体等无效。石炭酸系数为125。该品曾大量用于痱子、襁褓斑疹、面疱的治疗药及婴儿扑粉、药皂等。对氯酚对皮肤几乎没有刺激作用。
不溶于水，溶于醇、醚、丙酮、氯仿、丙二醇、聚乙二醇、橄榄油、棉子油和稀碱液。无气味或微带苯酚气味。
可燃性危险特性:可燃; 受热分解有毒氯化物气体
Sigma Aldrich:70-30-4(sigmaaldrich)
方法一:由2,4,5-三氯酚与甲醛或聚甲醛反应而得。将三氯酚、聚甲醛和硫酸搅拌混合，升温至75℃，反应液由稀薄变得稠厚，又立即由稠厚变为稀薄，将反应液倒入大量冰水中。过滤，滤饼用热水洗至中性，用稀碱溶解后加热至90℃，加入保险粉和活性炭，脱色30min。过滤，滤液加盐酸调节pH至2-3，冷至50℃以下，甩滤，滤饼用水洗涤，于80℃干燥，得六氯酚粗品。粗品经重结晶、精制即得成品。收率66%。另一种操作方法是使反应在溶剂二氯乙烷中进行，即将70g三氯酚、125ml二氯乙烷和32g20%发烟硫酸混合，加热至70-88℃，在1h内边搅拌边加入5.8g聚甲醛。全部加完后，回流1.5h，慢慢加入125ml二氯乙烷。停止搅拌，从底部将重硫酸层分离，用62ml二氯乙烷分两次提取硫酸层。将提取液与反应液分出的二氯乙烷层合并，加3g脱色炭脱色，然后在80℃过滤，加125ml水后，用水蒸汽蒸馏，将馏出物中悬浮的生成物滤出，干燥，得67.5-70g六氯酚。
TCI Shanghai:2,2’-亚甲基双(3,4,6-三氯苯酚) Hexachlorophene,>;98.0%(T)(70-30-4)
急性毒性:口服-大鼠 LD50: 56 毫克/公斤; 口服-小鼠 LD50: 67 毫克/公斤
六氯芬价格(试剂级):更新日期产品编号产品名称包装价格 2011/04/16 M0219 六氯酚 Hexachlorophene 25G 835元