L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury.
CAS 684276-17-3 MFCD84276173
化学结构图
SMILES: O=c1[nH]c(SCCN2CCCCC2)nc2ccccc12
化学属性
| Mol. Weight | 289.39586 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury. |
|---|---|
| Formula | C15H19N3OS |
| Synonym | L2286; L 2286; L-2286. |
| IUPAC Name | 2-((2-(piperidin-1-yl)ethyl)thio)quinazolin-4(3H)-one |
| InChIKey | QEAAIHDHSHTGMZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H19N3OS/c19-14-12-6-2-3-7-13(12)16-15(17-14)20-11-10-18-8-4-1-5-9-18/h2-3,6-7H,1,4-5,8-11H2,(H,16,17,19) |
| Canonical SMILES | O=C1NC(SCCN2CCCCC2)=NC3=C1C=CC=C3 |
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- L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury.
