GW4869 dihydrochloride 4′,4′′-双-2-咪唑啉-2-基对苯二丙烯酰苯胺二盐酸盐
CAS 6823-69-4 MFCD06411564
化学结构图
SMILES: Cl.Cl.O=C(C=Cc1ccc(C=CC(=O)Nc2ccc(C3=NCCN3)cc2)cc1)Nc1ccc(C2=NCCN2)cc1
化学属性
| Mol. Formula | C30H28N6O2· 2HCl |
|---|---|
| Mol. Weight | 577.50 |
| Melting Point | >;300 °C |
别名和识别编码
| Chemical Name | P-Benzenediacrylanilide, 4′,4′′-Di-2-Imidazolin-2-Yl-, Dihydrochloride |
|---|---|
| MDL Number | MFCD06411564 |
| CAS Number | 6823-69-4 |
| Chemical Name Translation | 4′,4′′-双-2-咪唑啉-2-基对苯二丙烯酰苯胺二盐酸盐 |
| Synonym | GW 4869 GW-4869 GW4869 N,N'-Bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3,3'-p-phenylene-bis-acrylamide dihydrochloride |
| PubChem Substance ID | 16078967 |
| LabNetwork Molecule ID | LN03243792 |
| InChI | InChI=1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5+,16-6+;; |
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分类
- {SNA} Approved Therapeutics/Drug Candidates,
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, G, GlaxoSmithKline, R to Z, Sphingomyelinase (neutral), 生物活性小分子, 细胞生物学,
相关文献及参考
- [2]. Essandoh K, et al. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Biochim Biophys Acta. 2015 Nov;1852(11):2362-71.
- [3]. Chen L, et al. Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes. FEBS Lett. 2016 Dec;590(23):4263-4274.
- [4]. Nakamura H, et al. Sphingomyelin Regulates the Activity of Secretory Phospholipase A2 in the Plasma Membrane. J Cell Biochem. 2015 Sep;116(9):1898-907.
- [1]. Luberto C, et al. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutralsphingomyelinase. J Biol Chem. 2002 Oct 25;277(43):41128-39.
- [1]. Luberto C, et al. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutralsphingomyelinase. J Biol Chem. 2002 Oct 25;277(43):41128-39.
- [2]. Essandoh K, et al. Blockade of exosome generation with GW4869 dampe
